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Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the widely perceived notion that malaria infections fa...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824751/ https://www.ncbi.nlm.nih.gov/pubmed/20174609 http://dx.doi.org/10.1371/journal.ppat.1000770 |
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author | Wipasa, Jiraprapa Suphavilai, Chaisuree Okell, Lucy C. Cook, Jackie Corran, Patrick H. Thaikla, Kanitta Liewsaree, Witaya Riley, Eleanor M. Hafalla, Julius Clemence R. |
author_facet | Wipasa, Jiraprapa Suphavilai, Chaisuree Okell, Lucy C. Cook, Jackie Corran, Patrick H. Thaikla, Kanitta Liewsaree, Witaya Riley, Eleanor M. Hafalla, Julius Clemence R. |
author_sort | Wipasa, Jiraprapa |
collection | PubMed |
description | Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the widely perceived notion that malaria infections fail to induce durable immunological memory responses. Currently, direct evidence for the presence or absence of immune memory to malaria is limited. In this study, we analysed the longevity of both antibody and B cell memory responses to malaria antigens among individuals who were living in an area of extremely low malaria transmission in northern Thailand, and who were known either to be malaria naïve or to have had a documented clinical attack of P. falciparum and/or P. vivax in the past 6 years. We found that exposure to malaria results in the generation of relatively avid antigen-specific antibodies and the establishment of populations of antigen-specific memory B cells in a significant proportion of malaria-exposed individuals. Both antibody and memory B cell responses to malaria antigens were stably maintained over time in the absence of reinfection. In a number of cases where antigen-specific antibodies were not detected in plasma, stable frequencies of antigen-specific memory B cells were nonetheless observed, suggesting that circulating memory B cells may be maintained independently of long-lived plasma cells. We conclude that infrequent malaria infections are capable of inducing long-lived antibody and memory B cell responses. |
format | Text |
id | pubmed-2824751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28247512010-02-19 Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax Wipasa, Jiraprapa Suphavilai, Chaisuree Okell, Lucy C. Cook, Jackie Corran, Patrick H. Thaikla, Kanitta Liewsaree, Witaya Riley, Eleanor M. Hafalla, Julius Clemence R. PLoS Pathog Research Article Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the widely perceived notion that malaria infections fail to induce durable immunological memory responses. Currently, direct evidence for the presence or absence of immune memory to malaria is limited. In this study, we analysed the longevity of both antibody and B cell memory responses to malaria antigens among individuals who were living in an area of extremely low malaria transmission in northern Thailand, and who were known either to be malaria naïve or to have had a documented clinical attack of P. falciparum and/or P. vivax in the past 6 years. We found that exposure to malaria results in the generation of relatively avid antigen-specific antibodies and the establishment of populations of antigen-specific memory B cells in a significant proportion of malaria-exposed individuals. Both antibody and memory B cell responses to malaria antigens were stably maintained over time in the absence of reinfection. In a number of cases where antigen-specific antibodies were not detected in plasma, stable frequencies of antigen-specific memory B cells were nonetheless observed, suggesting that circulating memory B cells may be maintained independently of long-lived plasma cells. We conclude that infrequent malaria infections are capable of inducing long-lived antibody and memory B cell responses. Public Library of Science 2010-02-19 /pmc/articles/PMC2824751/ /pubmed/20174609 http://dx.doi.org/10.1371/journal.ppat.1000770 Text en Wipasa et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wipasa, Jiraprapa Suphavilai, Chaisuree Okell, Lucy C. Cook, Jackie Corran, Patrick H. Thaikla, Kanitta Liewsaree, Witaya Riley, Eleanor M. Hafalla, Julius Clemence R. Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax |
title | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
|
title_full | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
|
title_fullStr | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
|
title_full_unstemmed | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
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title_short | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax
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title_sort | long-lived antibody and b cell memory responses to the human malaria parasites, plasmodium falciparum and plasmodium vivax |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824751/ https://www.ncbi.nlm.nih.gov/pubmed/20174609 http://dx.doi.org/10.1371/journal.ppat.1000770 |
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