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Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni

Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen bein...

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Autores principales: Wilson, Shona, Vennervald, Birgitte J., Kadzo, Hilda, Ireri, Edmund, Amaganga, Clifford, Booth, Mark, Kariuki, H. Curtis, Mwatha, Joseph K., Kimani, Gachuhi, Ouma, John H., Muchiri, Eric, Dunne, David W.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824847/
https://www.ncbi.nlm.nih.gov/pubmed/19818465
http://dx.doi.org/10.1016/j.trstmh.2009.08.006
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author Wilson, Shona
Vennervald, Birgitte J.
Kadzo, Hilda
Ireri, Edmund
Amaganga, Clifford
Booth, Mark
Kariuki, H. Curtis
Mwatha, Joseph K.
Kimani, Gachuhi
Ouma, John H.
Muchiri, Eric
Dunne, David W.
author_facet Wilson, Shona
Vennervald, Birgitte J.
Kadzo, Hilda
Ireri, Edmund
Amaganga, Clifford
Booth, Mark
Kariuki, H. Curtis
Mwatha, Joseph K.
Kimani, Gachuhi
Ouma, John H.
Muchiri, Eric
Dunne, David W.
author_sort Wilson, Shona
collection PubMed
description Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen being chronically enlarged and of a firm consistency. Where co-endemic, the two parasites are thought to synergistically exacerbate hepatosplenomegaly. Here, two potential health consequences, i.e. dilation of the portal vein (indicative of increased portal pressure) and stunting of growth, were investigated in a study area where children were chronically exposed to malaria throughout while S. mansoni transmission was geographically restricted. Hepatosplenomegaly was associated with increased portal vein diameters, with enlargement of the spleen rather than the liver being more closely associated with dilation. Dilation of the portal vein was exacerbated by S. mansoni infection in an intensity-dependent manner. The prevalence of growth stunting was not associated with either relative exposure rates to malarial infection or with S. mansoni infection status but was significantly associated with hepatosplenomegaly. Children who presented with hepatosplenomegaly had the lowest height-for-age Z-scores. This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences.
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spelling pubmed-28248472010-03-03 Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni Wilson, Shona Vennervald, Birgitte J. Kadzo, Hilda Ireri, Edmund Amaganga, Clifford Booth, Mark Kariuki, H. Curtis Mwatha, Joseph K. Kimani, Gachuhi Ouma, John H. Muchiri, Eric Dunne, David W. Trans R Soc Trop Med Hyg Article Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen being chronically enlarged and of a firm consistency. Where co-endemic, the two parasites are thought to synergistically exacerbate hepatosplenomegaly. Here, two potential health consequences, i.e. dilation of the portal vein (indicative of increased portal pressure) and stunting of growth, were investigated in a study area where children were chronically exposed to malaria throughout while S. mansoni transmission was geographically restricted. Hepatosplenomegaly was associated with increased portal vein diameters, with enlargement of the spleen rather than the liver being more closely associated with dilation. Dilation of the portal vein was exacerbated by S. mansoni infection in an intensity-dependent manner. The prevalence of growth stunting was not associated with either relative exposure rates to malarial infection or with S. mansoni infection status but was significantly associated with hepatosplenomegaly. Children who presented with hepatosplenomegaly had the lowest height-for-age Z-scores. This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences. Oxford University Press 2010-02 /pmc/articles/PMC2824847/ /pubmed/19818465 http://dx.doi.org/10.1016/j.trstmh.2009.08.006 Text en © 2010 Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Wilson, Shona
Vennervald, Birgitte J.
Kadzo, Hilda
Ireri, Edmund
Amaganga, Clifford
Booth, Mark
Kariuki, H. Curtis
Mwatha, Joseph K.
Kimani, Gachuhi
Ouma, John H.
Muchiri, Eric
Dunne, David W.
Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title_full Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title_fullStr Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title_full_unstemmed Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title_short Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
title_sort health implications of chronic hepatosplenomegaly in kenyan school-aged children chronically exposed to malarial infections and schistosoma mansoni
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824847/
https://www.ncbi.nlm.nih.gov/pubmed/19818465
http://dx.doi.org/10.1016/j.trstmh.2009.08.006
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