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Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

The receptor for calcitonin gene-related peptide (CGRP) has been the target for the development of novel small molecule antagonists for the treatment of migraine. Two such antagonists, BIBN4096BS and MK-0974, have shown great promise in clinical trials and hence a deeper understanding of the mechani...

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Detalles Bibliográficos
Autores principales:	Miller, Philip S., Barwell, James, Poyner, David R., Wigglesworth, Mark J., Garland, Stephen L., Donnelly, Dan
Formato:	Texto
Lenguaje:	English
Publicado:	Academic Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824848/ https://www.ncbi.nlm.nih.gov/pubmed/19914210 http://dx.doi.org/10.1016/j.bbrc.2009.11.076

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