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Promising treatments of tomorrow for multiple sclerosis
The therapeutic options for multiple sclerosis are rapidly expanding. What was once seen as a disease with little hope for treatment is now a target of rapid drug development. Current therapies have demonstrated efficacy in limiting the impact of the disease, but none is fully effective in all patie...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824956/ https://www.ncbi.nlm.nih.gov/pubmed/20182576 http://dx.doi.org/10.4103/0972-2327.58279 |
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author | Harrison, Daniel M. Calabresi, Peter A. |
author_facet | Harrison, Daniel M. Calabresi, Peter A. |
author_sort | Harrison, Daniel M. |
collection | PubMed |
description | The therapeutic options for multiple sclerosis are rapidly expanding. What was once seen as a disease with little hope for treatment is now a target of rapid drug development. Current therapies have demonstrated efficacy in limiting the impact of the disease, but none is fully effective in all patients. However, promising new treatments are on the horizon. In this review we will discuss potential novel immunomodulating drugs that are in advanced stages of investigation; these drugs include monoclonal antibodies, chimeric molecules, and oral therapies. The use of hematopoietic stem cells will also be discussed and, in addition, we will look farther ahead at possible novel targets for the development of new immunomodulatory or neuroprotective pharmaceuticals. |
format | Text |
id | pubmed-2824956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28249562010-02-24 Promising treatments of tomorrow for multiple sclerosis Harrison, Daniel M. Calabresi, Peter A. Ann Indian Acad Neurol Review: Management Updates The therapeutic options for multiple sclerosis are rapidly expanding. What was once seen as a disease with little hope for treatment is now a target of rapid drug development. Current therapies have demonstrated efficacy in limiting the impact of the disease, but none is fully effective in all patients. However, promising new treatments are on the horizon. In this review we will discuss potential novel immunomodulating drugs that are in advanced stages of investigation; these drugs include monoclonal antibodies, chimeric molecules, and oral therapies. The use of hematopoietic stem cells will also be discussed and, in addition, we will look farther ahead at possible novel targets for the development of new immunomodulatory or neuroprotective pharmaceuticals. Medknow Publications 2009 /pmc/articles/PMC2824956/ /pubmed/20182576 http://dx.doi.org/10.4103/0972-2327.58279 Text en © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review: Management Updates Harrison, Daniel M. Calabresi, Peter A. Promising treatments of tomorrow for multiple sclerosis |
title | Promising treatments of tomorrow for multiple sclerosis |
title_full | Promising treatments of tomorrow for multiple sclerosis |
title_fullStr | Promising treatments of tomorrow for multiple sclerosis |
title_full_unstemmed | Promising treatments of tomorrow for multiple sclerosis |
title_short | Promising treatments of tomorrow for multiple sclerosis |
title_sort | promising treatments of tomorrow for multiple sclerosis |
topic | Review: Management Updates |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824956/ https://www.ncbi.nlm.nih.gov/pubmed/20182576 http://dx.doi.org/10.4103/0972-2327.58279 |
work_keys_str_mv | AT harrisondanielm promisingtreatmentsoftomorrowformultiplesclerosis AT calabresipetera promisingtreatmentsoftomorrowformultiplesclerosis |