Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

[Image: see text] Ferrous ion and 2-oxoglutarate (2OG) oxygenases catalyze the demethylation of N(ε)-methylated lysine residues in histones. Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dy...

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Detalles Bibliográficos
Autores principales: Rose, Nathan R., Woon, Esther C. Y., Kingham, Guy L., King, Oliver N. F., Mecinović, Jasmin, Clifton, Ian J., Ng, Stanley S., Talib-Hardy, Jobina, Oppermann, Udo, McDonough, Michael A., Schofield, Christopher J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825117/
https://www.ncbi.nlm.nih.gov/pubmed/20088513
http://dx.doi.org/10.1021/jm901680b

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