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Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study

BACKGROUND: Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondrial dysfunction. Co-enzyme Q10 (Co-Q) is a nutritional supplement that has demon...

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Autores principales: Boles, Richard G, Lovett-Barr, Mary R, Preston, Amy, Li, B UK, Adams, Kathleen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825193/
https://www.ncbi.nlm.nih.gov/pubmed/20109231
http://dx.doi.org/10.1186/1471-2377-10-10
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author Boles, Richard G
Lovett-Barr, Mary R
Preston, Amy
Li, B UK
Adams, Kathleen
author_facet Boles, Richard G
Lovett-Barr, Mary R
Preston, Amy
Li, B UK
Adams, Kathleen
author_sort Boles, Richard G
collection PubMed
description BACKGROUND: Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondrial dysfunction. Co-enzyme Q10 (Co-Q) is a nutritional supplement that has demonstrated efficacy in pediatric and adult migraine. It is increasingly used in CVS despite the complete lack of studies to demonstrate its value in treatment METHODS: Using an Internet-based survey filled out by subjects with CVS or their parents, the efficacy, tolerability and subject satisfaction in CVS prophylaxis were queried. Subjects taking Co-Q (22 subjects) were compared against those taking amitriptyline (162 subjects), which is the general standard-of-care. RESULTS: Subjects/parents reported similar levels of efficacy for a variety of episode parameters (frequency, duration, number of emesis, nausea severity). There was a 50% reduction in at least one of those four parameters in 72% of subjects treated with amitriptyline and 68% of subjects treated Co-Q. However, while no side effects were reported on Co-Q, 50% of subjects on amitriptyline reported side effects (P = 5 × 10(-7)), resulting in 21% discontinuing treatment (P = 0.007). Subjects/parents considered the benefits to outweigh the risks of treatment in 47% of cases on amitriptyline and 77% of cases on Co-Q (P = 0.008). CONCLUSION: Our data suggest that the natural food supplement Co-Q is potentially efficacious and tolerable in the treatment of CVS, and should be considered as an option in CVS prophylaxis. Our data would likely be helpful in the design of a double-blind clinical trial.
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spelling pubmed-28251932010-02-20 Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study Boles, Richard G Lovett-Barr, Mary R Preston, Amy Li, B UK Adams, Kathleen BMC Neurol Research article BACKGROUND: Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondrial dysfunction. Co-enzyme Q10 (Co-Q) is a nutritional supplement that has demonstrated efficacy in pediatric and adult migraine. It is increasingly used in CVS despite the complete lack of studies to demonstrate its value in treatment METHODS: Using an Internet-based survey filled out by subjects with CVS or their parents, the efficacy, tolerability and subject satisfaction in CVS prophylaxis were queried. Subjects taking Co-Q (22 subjects) were compared against those taking amitriptyline (162 subjects), which is the general standard-of-care. RESULTS: Subjects/parents reported similar levels of efficacy for a variety of episode parameters (frequency, duration, number of emesis, nausea severity). There was a 50% reduction in at least one of those four parameters in 72% of subjects treated with amitriptyline and 68% of subjects treated Co-Q. However, while no side effects were reported on Co-Q, 50% of subjects on amitriptyline reported side effects (P = 5 × 10(-7)), resulting in 21% discontinuing treatment (P = 0.007). Subjects/parents considered the benefits to outweigh the risks of treatment in 47% of cases on amitriptyline and 77% of cases on Co-Q (P = 0.008). CONCLUSION: Our data suggest that the natural food supplement Co-Q is potentially efficacious and tolerable in the treatment of CVS, and should be considered as an option in CVS prophylaxis. Our data would likely be helpful in the design of a double-blind clinical trial. BioMed Central 2010-01-28 /pmc/articles/PMC2825193/ /pubmed/20109231 http://dx.doi.org/10.1186/1471-2377-10-10 Text en Copyright ©2010 Boles et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Boles, Richard G
Lovett-Barr, Mary R
Preston, Amy
Li, B UK
Adams, Kathleen
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title_full Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title_fullStr Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title_full_unstemmed Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title_short Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
title_sort treatment of cyclic vomiting syndrome with co-enzyme q10 and amitriptyline, a retrospective study
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825193/
https://www.ncbi.nlm.nih.gov/pubmed/20109231
http://dx.doi.org/10.1186/1471-2377-10-10
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