FOXP3 and GARP (LRRC32): the master and its minion

The transcription factor FOXP3 is essential for the development and function of CD4(+)CD25(hi)FOXP3(+ )regulatory T (T(reg)) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP...

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Detalles Bibliográficos
Autores principales: Probst-Kepper, Michael, Buer, Jan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825496/
https://www.ncbi.nlm.nih.gov/pubmed/20137067
http://dx.doi.org/10.1186/1745-6150-5-8
Descripción
Sumario:The transcription factor FOXP3 is essential for the development and function of CD4(+)CD25(hi)FOXP3(+ )regulatory T (T(reg)) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP or LRRC32) recently identified as specific marker of activated human T(reg )cells, which may provide the missing link toward a better molecular definition of the regulatory phenotype. Reviewers: Dr Jim Di Danto, Dr Benedita Rocha and Dr Werner Solbach.

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