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Remodeling of inhibitory synaptic connections in developing ferret visual cortex
BACKGROUND: In the visual cortex, as in many other regions of the developing brain, excitatory synaptic connections undergo substantial remodeling during development. While evidence suggests that local inhibitory synapses may behave similarly, the extent and mechanisms that mediate remodeling of inh...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825501/ https://www.ncbi.nlm.nih.gov/pubmed/20122141 http://dx.doi.org/10.1186/1749-8104-5-5 |
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author | Dalva, Matthew B |
author_facet | Dalva, Matthew B |
author_sort | Dalva, Matthew B |
collection | PubMed |
description | BACKGROUND: In the visual cortex, as in many other regions of the developing brain, excitatory synaptic connections undergo substantial remodeling during development. While evidence suggests that local inhibitory synapses may behave similarly, the extent and mechanisms that mediate remodeling of inhibitory connections are not well understood. RESULTS: Using scanning laser photostimulation in slices of developing ferret visual cortex, we assessed the overall patterns of developing inhibitory and excitatory synaptic connections converging onto individual neurons. Inhibitory synaptic inputs onto pyramidal neurons in cortical layers 2 and 3 were already present as early as postnatal day 20, well before eye opening, and originated from regions close to the recorded neurons. During the ensuing 2 weeks, the numbers of synaptic inputs increased, with the numbers of inhibitory (and excitatory) synaptic inputs peaking near the time of eye opening. The pattern of inhibitory inputs refined rapidly prior to the refinement of excitatory inputs. By uncaging the neurotransmtter GABA in brain slices from animals of different ages, we find that this rapid refinement correlated with a loss of excitatory activity by GABA. CONCLUSION: Inhibitory synapses, like excitatory synapses, undergo significant postnatal remodeling. The time course of the remodeling of inhibitory connections correlates with the emergence of orientation tuning in the visual cortex, implicating these rearrangements in the genesis of adult cortical response properties. |
format | Text |
id | pubmed-2825501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28255012010-02-21 Remodeling of inhibitory synaptic connections in developing ferret visual cortex Dalva, Matthew B Neural Dev Research article BACKGROUND: In the visual cortex, as in many other regions of the developing brain, excitatory synaptic connections undergo substantial remodeling during development. While evidence suggests that local inhibitory synapses may behave similarly, the extent and mechanisms that mediate remodeling of inhibitory connections are not well understood. RESULTS: Using scanning laser photostimulation in slices of developing ferret visual cortex, we assessed the overall patterns of developing inhibitory and excitatory synaptic connections converging onto individual neurons. Inhibitory synaptic inputs onto pyramidal neurons in cortical layers 2 and 3 were already present as early as postnatal day 20, well before eye opening, and originated from regions close to the recorded neurons. During the ensuing 2 weeks, the numbers of synaptic inputs increased, with the numbers of inhibitory (and excitatory) synaptic inputs peaking near the time of eye opening. The pattern of inhibitory inputs refined rapidly prior to the refinement of excitatory inputs. By uncaging the neurotransmtter GABA in brain slices from animals of different ages, we find that this rapid refinement correlated with a loss of excitatory activity by GABA. CONCLUSION: Inhibitory synapses, like excitatory synapses, undergo significant postnatal remodeling. The time course of the remodeling of inhibitory connections correlates with the emergence of orientation tuning in the visual cortex, implicating these rearrangements in the genesis of adult cortical response properties. BioMed Central 2010-02-01 /pmc/articles/PMC2825501/ /pubmed/20122141 http://dx.doi.org/10.1186/1749-8104-5-5 Text en Copyright ©2010 Dalva; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Dalva, Matthew B Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title | Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title_full | Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title_fullStr | Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title_full_unstemmed | Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title_short | Remodeling of inhibitory synaptic connections in developing ferret visual cortex |
title_sort | remodeling of inhibitory synaptic connections in developing ferret visual cortex |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825501/ https://www.ncbi.nlm.nih.gov/pubmed/20122141 http://dx.doi.org/10.1186/1749-8104-5-5 |
work_keys_str_mv | AT dalvamatthewb remodelingofinhibitorysynapticconnectionsindevelopingferretvisualcortex |