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Cellular Stress Responses: Cell Survival and Cell Death

Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as...

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Detalles Bibliográficos
Autores principales: Fulda, Simone, Gorman, Adrienne M., Hori, Osamu, Samali, Afshin
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825543/
https://www.ncbi.nlm.nih.gov/pubmed/20182529
http://dx.doi.org/10.1155/2010/214074
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author Fulda, Simone
Gorman, Adrienne M.
Hori, Osamu
Samali, Afshin
author_facet Fulda, Simone
Gorman, Adrienne M.
Hori, Osamu
Samali, Afshin
author_sort Fulda, Simone
collection PubMed
description Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.
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spelling pubmed-28255432010-02-24 Cellular Stress Responses: Cell Survival and Cell Death Fulda, Simone Gorman, Adrienne M. Hori, Osamu Samali, Afshin Int J Cell Biol Review Article Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer. Hindawi Publishing Corporation 2010 2010-02-21 /pmc/articles/PMC2825543/ /pubmed/20182529 http://dx.doi.org/10.1155/2010/214074 Text en Copyright © 2010 Simone Fulda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fulda, Simone
Gorman, Adrienne M.
Hori, Osamu
Samali, Afshin
Cellular Stress Responses: Cell Survival and Cell Death
title Cellular Stress Responses: Cell Survival and Cell Death
title_full Cellular Stress Responses: Cell Survival and Cell Death
title_fullStr Cellular Stress Responses: Cell Survival and Cell Death
title_full_unstemmed Cellular Stress Responses: Cell Survival and Cell Death
title_short Cellular Stress Responses: Cell Survival and Cell Death
title_sort cellular stress responses: cell survival and cell death
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825543/
https://www.ncbi.nlm.nih.gov/pubmed/20182529
http://dx.doi.org/10.1155/2010/214074
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