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Cellular Stress Responses: Cell Survival and Cell Death
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825543/ https://www.ncbi.nlm.nih.gov/pubmed/20182529 http://dx.doi.org/10.1155/2010/214074 |
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author | Fulda, Simone Gorman, Adrienne M. Hori, Osamu Samali, Afshin |
author_facet | Fulda, Simone Gorman, Adrienne M. Hori, Osamu Samali, Afshin |
author_sort | Fulda, Simone |
collection | PubMed |
description | Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer. |
format | Text |
id | pubmed-2825543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28255432010-02-24 Cellular Stress Responses: Cell Survival and Cell Death Fulda, Simone Gorman, Adrienne M. Hori, Osamu Samali, Afshin Int J Cell Biol Review Article Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer. Hindawi Publishing Corporation 2010 2010-02-21 /pmc/articles/PMC2825543/ /pubmed/20182529 http://dx.doi.org/10.1155/2010/214074 Text en Copyright © 2010 Simone Fulda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fulda, Simone Gorman, Adrienne M. Hori, Osamu Samali, Afshin Cellular Stress Responses: Cell Survival and Cell Death |
title | Cellular Stress Responses: Cell Survival and Cell Death |
title_full | Cellular Stress Responses: Cell Survival and Cell Death |
title_fullStr | Cellular Stress Responses: Cell Survival and Cell Death |
title_full_unstemmed | Cellular Stress Responses: Cell Survival and Cell Death |
title_short | Cellular Stress Responses: Cell Survival and Cell Death |
title_sort | cellular stress responses: cell survival and cell death |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825543/ https://www.ncbi.nlm.nih.gov/pubmed/20182529 http://dx.doi.org/10.1155/2010/214074 |
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