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Regulation of mRNA cap methylation
The 7-methylguanosine cap added to the 5′ end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, c...
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Formato: | Texto |
Lenguaje: | English |
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Portland Press Ltd.
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825737/ https://www.ncbi.nlm.nih.gov/pubmed/20025612 http://dx.doi.org/10.1042/BJ20091352 |
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author | Cowling, Victoria H. |
author_facet | Cowling, Victoria H. |
author_sort | Cowling, Victoria H. |
collection | PubMed |
description | The 7-methylguanosine cap added to the 5′ end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated. |
format | Text |
id | pubmed-2825737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-28257372010-02-23 Regulation of mRNA cap methylation Cowling, Victoria H. Biochem J Review Article The 7-methylguanosine cap added to the 5′ end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated. Portland Press Ltd. 2009-12-23 2010-01-15 /pmc/articles/PMC2825737/ /pubmed/20025612 http://dx.doi.org/10.1042/BJ20091352 Text en © 2010 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cowling, Victoria H. Regulation of mRNA cap methylation |
title | Regulation of mRNA cap methylation |
title_full | Regulation of mRNA cap methylation |
title_fullStr | Regulation of mRNA cap methylation |
title_full_unstemmed | Regulation of mRNA cap methylation |
title_short | Regulation of mRNA cap methylation |
title_sort | regulation of mrna cap methylation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825737/ https://www.ncbi.nlm.nih.gov/pubmed/20025612 http://dx.doi.org/10.1042/BJ20091352 |
work_keys_str_mv | AT cowlingvictoriah regulationofmrnacapmethylation |