Cargando…

TGF-β signalling is regulated by Schnurri-2 dependent nuclear translocation of CLIC4 and consequent stabilization of phospho Smad2–3

CLIC4, a multifunctional protein that traffics between the cytoplasm and nucleus, interacts with Schnurri-2, a transcription factor in the BMP pathway. TGF-β enhances the expression of both CLIC4 and Schnurri-2 and promotes their association in the cytoplasm and their translocation to the nucleus. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shukla, Anjali, Malik, Mariam, Cataisson, Christophe, Ho, Yan, Friesen, Travis, Suh, Kwang S., Yuspa, Stuart H.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825893/ https://www.ncbi.nlm.nih.gov/pubmed/19448624 http://dx.doi.org/10.1038/ncb1885

Ejemplares similares

Elevating CLIC4 in Multiple Cell Types Reveals a TGF-β Dependent Induction of a Dominant Negative Smad7 Splice Variant
por: Shukla, Anjali, et al.
Publicado: (2016)

CLIC4 regulates TGF-β dependent myofibroblast differentiation to produce a cancer stroma
por: Shukla, A, et al.
Publicado: (2013)

Dampening of death pathways by Schnurri 2 is essential for T cell development
por: Staton, Tracy L., et al.
Publicado: (2011)

Regulation of T helper type 2 cell differentiation by murine Schnurri-2
por: Kimura, Motoko Y., et al.
Publicado: (2005)

Arkadia Enhances Nodal/TGF-β Signaling by Coupling Phospho-Smad2/3 Activity and Turnover
por: Mavrakis, Konstantinos J, et al.
Publicado: (2007)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK
por: Jeong, Ji-Hoon, et al.
Publicado: (2020)

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis
por: Yoshida, Katsunori, et al.
Publicado: (2018)

The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila Embryos
por: Beira, Jorge V., et al.
Publicado: (2014)

TGFβ pathway deregulation and abnormal phospho‐SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis‐Dutch type
por: Grand Moursel, Laure, et al.
Publicado: (2017)

Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis
por: Stavre, Zheni, et al.
Publicado: (2023)

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4
por: Carofino, Brandi L., et al.
Publicado: (2019)

Schnurri-3 (KRC) Interacts with c-Jun to Regulate the IL-2 Gene in T Cells
por: Oukka, Mohamed, et al.
Publicado: (2004)

Biomechanical and Bone Material Properties of Schnurri‐3 Null Mice
por: Hofstaetter, Jochen G, et al.
Publicado: (2019)

The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells
por: Al Khamici, Heba, et al.
Publicado: (2022)

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease
por: McNair, Andrew J., et al.
Publicado: (2023)

Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis
por: Yamaguchi, Takashi, et al.
Publicado: (2022)

Schnurri 3 promotes Th2 cytokine production during the late phase of T‐cell antigen stimulation
por: Cunha, Christina, et al.
Publicado: (2022)

Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas
por: Liu, Chunhui, et al.
Publicado: (2016)

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence
por: Sanchez, Vanesa C., et al.
Publicado: (2022)

Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2
por: Bartolomé, Rubén A., et al.
Publicado: (2023)

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
por: Yang, Yeon-Suk, et al.
Publicado: (2019)

Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia
por: Kobayashi, Katsunori, et al.
Publicado: (2018)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions
por: Yoshida, Katsunori, et al.
Publicado: (2016)

Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis
por: Suwa, Kanehiko, et al.
Publicado: (2020)

Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation
por: Eritja, Núria, et al.
Publicado: (2021)

Osteopontin and phospho‐SMAD2/3 are associated with calcification of vessels in D‐CAA, an hereditary cerebral amyloid angiopathy
por: Grand Moursel, Laure, et al.
Publicado: (2019)

Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability
por: Nakao, Akito, et al.
Publicado: (2017)

Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8
por: Ahn, Byul-Nim, et al.
Publicado: (2016)

The identification and structural analysis of potential 14-3-3 interaction sites on the bone regulator protein Schnurri-3
por: Soini, Lorenzo, et al.
Publicado: (2021)

Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation
por: Hu, Wenyu, et al.
Publicado: (2021)

Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation
por: Azamov, Bakhovuddin, et al.
Publicado: (2023)

TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation
por: Albers, Renee E., et al.
Publicado: (2018)

TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
por: Zhang, Chao, et al.
Publicado: (2017)

TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors
por: Law, Alick KT, et al.
Publicado: (2004)

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells
por: Kim, Jinkyoung, et al.
Publicado: (2016)

Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model
por: Thomsen, Lise Høj, et al.
Publicado: (2017)

Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia
por: Takao, Keizo, et al.
Publicado: (2013)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u70cij4ucjvvdv7cculhvgdpt4