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Hematopoietic stem cells and retroviral infection
Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826343/ https://www.ncbi.nlm.nih.gov/pubmed/20132553 http://dx.doi.org/10.1186/1742-4690-7-8 |
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author | Banerjee, Prabal Crawford, Lindsey Samuelson, Elizabeth Feuer, Gerold |
author_facet | Banerjee, Prabal Crawford, Lindsey Samuelson, Elizabeth Feuer, Gerold |
author_sort | Banerjee, Prabal |
collection | PubMed |
description | Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of leukemia/lymphoma. Research over the last few decades has elucidated similarities between retroviral-induced leukemogenesis, initiated by deregulation of innate hematopoietic stem cell traits, and the cancer stem cell hypothesis. Ongoing research in some of these models may provide a better understanding of the processes of normal hematopoiesis and cancer stem cells. Research on retroviral induced leukemias and lymphomas may identify the molecular events which trigger the initial cellular transformation and subsequent maintenance of hematologic malignancies, including the generation of cancer stem cells. This review focuses on the role of retroviral infection in hematopoietic stem cells and the initiation, maintenance and progression of hematological malignancies. |
format | Text |
id | pubmed-2826343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28263432010-02-23 Hematopoietic stem cells and retroviral infection Banerjee, Prabal Crawford, Lindsey Samuelson, Elizabeth Feuer, Gerold Retrovirology Review Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of leukemia/lymphoma. Research over the last few decades has elucidated similarities between retroviral-induced leukemogenesis, initiated by deregulation of innate hematopoietic stem cell traits, and the cancer stem cell hypothesis. Ongoing research in some of these models may provide a better understanding of the processes of normal hematopoiesis and cancer stem cells. Research on retroviral induced leukemias and lymphomas may identify the molecular events which trigger the initial cellular transformation and subsequent maintenance of hematologic malignancies, including the generation of cancer stem cells. This review focuses on the role of retroviral infection in hematopoietic stem cells and the initiation, maintenance and progression of hematological malignancies. BioMed Central 2010-02-04 /pmc/articles/PMC2826343/ /pubmed/20132553 http://dx.doi.org/10.1186/1742-4690-7-8 Text en Copyright ©2010 Banerjee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Banerjee, Prabal Crawford, Lindsey Samuelson, Elizabeth Feuer, Gerold Hematopoietic stem cells and retroviral infection |
title | Hematopoietic stem cells and retroviral infection |
title_full | Hematopoietic stem cells and retroviral infection |
title_fullStr | Hematopoietic stem cells and retroviral infection |
title_full_unstemmed | Hematopoietic stem cells and retroviral infection |
title_short | Hematopoietic stem cells and retroviral infection |
title_sort | hematopoietic stem cells and retroviral infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826343/ https://www.ncbi.nlm.nih.gov/pubmed/20132553 http://dx.doi.org/10.1186/1742-4690-7-8 |
work_keys_str_mv | AT banerjeeprabal hematopoieticstemcellsandretroviralinfection AT crawfordlindsey hematopoieticstemcellsandretroviralinfection AT samuelsonelizabeth hematopoieticstemcellsandretroviralinfection AT feuergerold hematopoieticstemcellsandretroviralinfection |