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Hematopoietic stem cells and retroviral infection

Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells...

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Detalles Bibliográficos
Autores principales: Banerjee, Prabal, Crawford, Lindsey, Samuelson, Elizabeth, Feuer, Gerold
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826343/
https://www.ncbi.nlm.nih.gov/pubmed/20132553
http://dx.doi.org/10.1186/1742-4690-7-8
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author Banerjee, Prabal
Crawford, Lindsey
Samuelson, Elizabeth
Feuer, Gerold
author_facet Banerjee, Prabal
Crawford, Lindsey
Samuelson, Elizabeth
Feuer, Gerold
author_sort Banerjee, Prabal
collection PubMed
description Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of leukemia/lymphoma. Research over the last few decades has elucidated similarities between retroviral-induced leukemogenesis, initiated by deregulation of innate hematopoietic stem cell traits, and the cancer stem cell hypothesis. Ongoing research in some of these models may provide a better understanding of the processes of normal hematopoiesis and cancer stem cells. Research on retroviral induced leukemias and lymphomas may identify the molecular events which trigger the initial cellular transformation and subsequent maintenance of hematologic malignancies, including the generation of cancer stem cells. This review focuses on the role of retroviral infection in hematopoietic stem cells and the initiation, maintenance and progression of hematological malignancies.
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spelling pubmed-28263432010-02-23 Hematopoietic stem cells and retroviral infection Banerjee, Prabal Crawford, Lindsey Samuelson, Elizabeth Feuer, Gerold Retrovirology Review Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of leukemia/lymphoma. Research over the last few decades has elucidated similarities between retroviral-induced leukemogenesis, initiated by deregulation of innate hematopoietic stem cell traits, and the cancer stem cell hypothesis. Ongoing research in some of these models may provide a better understanding of the processes of normal hematopoiesis and cancer stem cells. Research on retroviral induced leukemias and lymphomas may identify the molecular events which trigger the initial cellular transformation and subsequent maintenance of hematologic malignancies, including the generation of cancer stem cells. This review focuses on the role of retroviral infection in hematopoietic stem cells and the initiation, maintenance and progression of hematological malignancies. BioMed Central 2010-02-04 /pmc/articles/PMC2826343/ /pubmed/20132553 http://dx.doi.org/10.1186/1742-4690-7-8 Text en Copyright ©2010 Banerjee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Banerjee, Prabal
Crawford, Lindsey
Samuelson, Elizabeth
Feuer, Gerold
Hematopoietic stem cells and retroviral infection
title Hematopoietic stem cells and retroviral infection
title_full Hematopoietic stem cells and retroviral infection
title_fullStr Hematopoietic stem cells and retroviral infection
title_full_unstemmed Hematopoietic stem cells and retroviral infection
title_short Hematopoietic stem cells and retroviral infection
title_sort hematopoietic stem cells and retroviral infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826343/
https://www.ncbi.nlm.nih.gov/pubmed/20132553
http://dx.doi.org/10.1186/1742-4690-7-8
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