Spatial regulation and organization of DNA replication within the nucleus

Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized...

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Detalles Bibliográficos
Autores principales: Natsume, Toyoaki, Tanaka, Tomoyuki U.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826631/
https://www.ncbi.nlm.nih.gov/pubmed/19856119
http://dx.doi.org/10.1007/s10577-009-9088-0
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author Natsume, Toyoaki
Tanaka, Tomoyuki U.
author_facet Natsume, Toyoaki
Tanaka, Tomoyuki U.
author_sort Natsume, Toyoaki
collection PubMed
description Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.
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spelling pubmed-28266312010-03-05 Spatial regulation and organization of DNA replication within the nucleus Natsume, Toyoaki Tanaka, Tomoyuki U. Chromosome Res Article Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans. Springer Netherlands 2009-10-24 2010 /pmc/articles/PMC2826631/ /pubmed/19856119 http://dx.doi.org/10.1007/s10577-009-9088-0 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Natsume, Toyoaki
Tanaka, Tomoyuki U.
Spatial regulation and organization of DNA replication within the nucleus
title Spatial regulation and organization of DNA replication within the nucleus
title_full Spatial regulation and organization of DNA replication within the nucleus
title_fullStr Spatial regulation and organization of DNA replication within the nucleus
title_full_unstemmed Spatial regulation and organization of DNA replication within the nucleus
title_short Spatial regulation and organization of DNA replication within the nucleus
title_sort spatial regulation and organization of dna replication within the nucleus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826631/
https://www.ncbi.nlm.nih.gov/pubmed/19856119
http://dx.doi.org/10.1007/s10577-009-9088-0
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