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Capecitabine-induced cardiotoxicity: case report and review of the literature
Capecitabine, an oral prodrug of 5-fluorouracil (5fu), has been integrated into the management of multiple cancer types because of convenience of administration and efficacy comparable with 5fu. Cardiotoxicity induced by 5fu—in particular angina—has been well described in the literature, but reports...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Multimed Inc.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826779/ https://www.ncbi.nlm.nih.gov/pubmed/20179805 |
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author | Ang, C. Kornbluth, M. Thirlwell, M.P. Rajan, R.D. |
author_facet | Ang, C. Kornbluth, M. Thirlwell, M.P. Rajan, R.D. |
author_sort | Ang, C. |
collection | PubMed |
description | Capecitabine, an oral prodrug of 5-fluorouracil (5fu), has been integrated into the management of multiple cancer types because of convenience of administration and efficacy comparable with 5fu. Cardiotoxicity induced by 5fu—in particular angina—has been well described in the literature, but reports of adverse cardiac events with capecitabine are also emerging. The mechanism underlying 5fu cardiotoxicity has long been thought to result from coronary vasospasm, but animal-model studies and patient echocardiographic findings both suggest a cardiomyopathic picture. Although 5fu cardiotoxicity is often reversible and can be managed supportively, presentations that are more severe—including arrhythmias, acute ischemic events, and cardiogenic shock—have been documented. In this report, we describe the case of a patient who ultimately required a pacemaker after developing symptomatic bradycardia and sinus arrest while receiving capecitabine for colon cancer. |
format | Text |
id | pubmed-2826779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Multimed Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-28267792010-02-23 Capecitabine-induced cardiotoxicity: case report and review of the literature Ang, C. Kornbluth, M. Thirlwell, M.P. Rajan, R.D. Curr Oncol Case Report Capecitabine, an oral prodrug of 5-fluorouracil (5fu), has been integrated into the management of multiple cancer types because of convenience of administration and efficacy comparable with 5fu. Cardiotoxicity induced by 5fu—in particular angina—has been well described in the literature, but reports of adverse cardiac events with capecitabine are also emerging. The mechanism underlying 5fu cardiotoxicity has long been thought to result from coronary vasospasm, but animal-model studies and patient echocardiographic findings both suggest a cardiomyopathic picture. Although 5fu cardiotoxicity is often reversible and can be managed supportively, presentations that are more severe—including arrhythmias, acute ischemic events, and cardiogenic shock—have been documented. In this report, we describe the case of a patient who ultimately required a pacemaker after developing symptomatic bradycardia and sinus arrest while receiving capecitabine for colon cancer. Multimed Inc. 2010-02 /pmc/articles/PMC2826779/ /pubmed/20179805 Text en 2010 Multimed Inc. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ang, C. Kornbluth, M. Thirlwell, M.P. Rajan, R.D. Capecitabine-induced cardiotoxicity: case report and review of the literature |
title | Capecitabine-induced cardiotoxicity: case report and review of the literature |
title_full | Capecitabine-induced cardiotoxicity: case report and review of the literature |
title_fullStr | Capecitabine-induced cardiotoxicity: case report and review of the literature |
title_full_unstemmed | Capecitabine-induced cardiotoxicity: case report and review of the literature |
title_short | Capecitabine-induced cardiotoxicity: case report and review of the literature |
title_sort | capecitabine-induced cardiotoxicity: case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826779/ https://www.ncbi.nlm.nih.gov/pubmed/20179805 |
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