Regulation of IL-9 expression by IL-25 signaling

The physiological regulation of interleukin 9 (IL-9) expression, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of TGF-β and interleukin 4 (IL-4) express high levels of interleukin 17 recepto...

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Autores principales: Angkasekwinai, Pornpimon, Chang, Seon Hee, Thapa, Manoj, Watarai, Hiroshi, Dong, Chen
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827302/
https://www.ncbi.nlm.nih.gov/pubmed/20154671
http://dx.doi.org/10.1038/ni.1846
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author Angkasekwinai, Pornpimon
Chang, Seon Hee
Thapa, Manoj
Watarai, Hiroshi
Dong, Chen
author_facet Angkasekwinai, Pornpimon
Chang, Seon Hee
Thapa, Manoj
Watarai, Hiroshi
Dong, Chen
author_sort Angkasekwinai, Pornpimon
collection PubMed
description The physiological regulation of interleukin 9 (IL-9) expression, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of TGF-β and interleukin 4 (IL-4) express high levels of interleukin 17 receptor (IL-17R) B mRNA, the receptor for interleukin 25 (IL-25). Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral over-expression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.
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spelling pubmed-28273022010-09-01 Regulation of IL-9 expression by IL-25 signaling Angkasekwinai, Pornpimon Chang, Seon Hee Thapa, Manoj Watarai, Hiroshi Dong, Chen Nat Immunol Article The physiological regulation of interleukin 9 (IL-9) expression, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of TGF-β and interleukin 4 (IL-4) express high levels of interleukin 17 receptor (IL-17R) B mRNA, the receptor for interleukin 25 (IL-25). Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral over-expression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression. 2010-02-14 2010-03 /pmc/articles/PMC2827302/ /pubmed/20154671 http://dx.doi.org/10.1038/ni.1846 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Angkasekwinai, Pornpimon
Chang, Seon Hee
Thapa, Manoj
Watarai, Hiroshi
Dong, Chen
Regulation of IL-9 expression by IL-25 signaling
title Regulation of IL-9 expression by IL-25 signaling
title_full Regulation of IL-9 expression by IL-25 signaling
title_fullStr Regulation of IL-9 expression by IL-25 signaling
title_full_unstemmed Regulation of IL-9 expression by IL-25 signaling
title_short Regulation of IL-9 expression by IL-25 signaling
title_sort regulation of il-9 expression by il-25 signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827302/
https://www.ncbi.nlm.nih.gov/pubmed/20154671
http://dx.doi.org/10.1038/ni.1846
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AT thapamanoj regulationofil9expressionbyil25signaling
AT wataraihiroshi regulationofil9expressionbyil25signaling
AT dongchen regulationofil9expressionbyil25signaling

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