In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure

Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice...

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Autores principales: Chauveau, Fabien, Moucharrafie, Samir, Wiart, Marlène, Brisset, Jean-Christophe, Berthezène, Yves, Nighoghossian, Norbert, Cho, Tae-Hee
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827391/
https://www.ncbi.nlm.nih.gov/pubmed/20298536
http://dx.doi.org/10.1186/2040-7378-2-4
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author Chauveau, Fabien
Moucharrafie, Samir
Wiart, Marlène
Brisset, Jean-Christophe
Berthezène, Yves
Nighoghossian, Norbert
Cho, Tae-Hee
author_facet Chauveau, Fabien
Moucharrafie, Samir
Wiart, Marlène
Brisset, Jean-Christophe
Berthezène, Yves
Nighoghossian, Norbert
Cho, Tae-Hee
author_sort Chauveau, Fabien
collection PubMed
description Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment.
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spelling pubmed-28273912010-02-24 In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure Chauveau, Fabien Moucharrafie, Samir Wiart, Marlène Brisset, Jean-Christophe Berthezène, Yves Nighoghossian, Norbert Cho, Tae-Hee Exp Transl Stroke Med Short Report Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment. BioMed Central 2010-02-04 /pmc/articles/PMC2827391/ /pubmed/20298536 http://dx.doi.org/10.1186/2040-7378-2-4 Text en Copyright ©2010 Chauveau et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Chauveau, Fabien
Moucharrafie, Samir
Wiart, Marlène
Brisset, Jean-Christophe
Berthezène, Yves
Nighoghossian, Norbert
Cho, Tae-Hee
In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title_full In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title_fullStr In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title_full_unstemmed In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title_short In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
title_sort in vivo mri assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827391/
https://www.ncbi.nlm.nih.gov/pubmed/20298536
http://dx.doi.org/10.1186/2040-7378-2-4
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