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Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control

BACKGROUND: Eating disorders are multifactorial psychiatric disorders. Chronic stressful experiences and caloric restriction are the most powerful triggers of eating disorders in human and animals. Although compulsive behavior is considered to characterize pathological excessive food intake, to our...

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Autores principales: Latagliata, Emanuele Claudio, Patrono, Enrico, Puglisi-Allegra, Stefano, Ventura, Rossella
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827417/
https://www.ncbi.nlm.nih.gov/pubmed/20141625
http://dx.doi.org/10.1186/1471-2202-11-15
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author Latagliata, Emanuele Claudio
Patrono, Enrico
Puglisi-Allegra, Stefano
Ventura, Rossella
author_facet Latagliata, Emanuele Claudio
Patrono, Enrico
Puglisi-Allegra, Stefano
Ventura, Rossella
author_sort Latagliata, Emanuele Claudio
collection PubMed
description BACKGROUND: Eating disorders are multifactorial psychiatric disorders. Chronic stressful experiences and caloric restriction are the most powerful triggers of eating disorders in human and animals. Although compulsive behavior is considered to characterize pathological excessive food intake, to our knowledge, no evidence has been reported of continued food seeking/intake despite its possible harmful consequences, an index of compulsive behavior. Brain monoamine transmission is considered to have a key role in vulnerability to eating disorders, and norepinephrine in medial prefrontal cortex has been shown to be critical for food-related motivated behavior. Here, using a new paradigm of conditioned suppression, we investigated whether the ability of a foot-shock-paired conditioned stimulus to suppress chocolate-seeking behavior was reversed by previous exposure to a food restriction experience, thus modeling food seeking in spite of harmful consequences in mice. Moreover, we assessed the effects of selective norepinephrine inactivation in medial prefrontal cortex on conditioned suppression test in stressed and caloric restricted mice. RESULTS: While Control (non food deprived) animals showed a profound conditioned suppression of chocolate seeking during presentation of conditioned stimulus, previously food restricted animals showed food seeking/intake despite its possible harmful consequences. Moreover, food seeking in spite of harmful consequences was prevented by selective norepinephrine inactivation, thus showing that prefrontal cortical norepinephrine is critical also for maladaptive food-related behavior. CONCLUSIONS: These findings indicate that adaptive food seeking/intake can be transformed into maladaptive behaviors and point to "top-down" influence on eating disturbances and to new targets for therapy of aberrant eating behaviors.
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spelling pubmed-28274172010-02-24 Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control Latagliata, Emanuele Claudio Patrono, Enrico Puglisi-Allegra, Stefano Ventura, Rossella BMC Neurosci Research article BACKGROUND: Eating disorders are multifactorial psychiatric disorders. Chronic stressful experiences and caloric restriction are the most powerful triggers of eating disorders in human and animals. Although compulsive behavior is considered to characterize pathological excessive food intake, to our knowledge, no evidence has been reported of continued food seeking/intake despite its possible harmful consequences, an index of compulsive behavior. Brain monoamine transmission is considered to have a key role in vulnerability to eating disorders, and norepinephrine in medial prefrontal cortex has been shown to be critical for food-related motivated behavior. Here, using a new paradigm of conditioned suppression, we investigated whether the ability of a foot-shock-paired conditioned stimulus to suppress chocolate-seeking behavior was reversed by previous exposure to a food restriction experience, thus modeling food seeking in spite of harmful consequences in mice. Moreover, we assessed the effects of selective norepinephrine inactivation in medial prefrontal cortex on conditioned suppression test in stressed and caloric restricted mice. RESULTS: While Control (non food deprived) animals showed a profound conditioned suppression of chocolate seeking during presentation of conditioned stimulus, previously food restricted animals showed food seeking/intake despite its possible harmful consequences. Moreover, food seeking in spite of harmful consequences was prevented by selective norepinephrine inactivation, thus showing that prefrontal cortical norepinephrine is critical also for maladaptive food-related behavior. CONCLUSIONS: These findings indicate that adaptive food seeking/intake can be transformed into maladaptive behaviors and point to "top-down" influence on eating disturbances and to new targets for therapy of aberrant eating behaviors. BioMed Central 2010-02-08 /pmc/articles/PMC2827417/ /pubmed/20141625 http://dx.doi.org/10.1186/1471-2202-11-15 Text en Copyright ©2010 Latagliata et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Latagliata, Emanuele Claudio
Patrono, Enrico
Puglisi-Allegra, Stefano
Ventura, Rossella
Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title_full Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title_fullStr Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title_full_unstemmed Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title_short Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
title_sort food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827417/
https://www.ncbi.nlm.nih.gov/pubmed/20141625
http://dx.doi.org/10.1186/1471-2202-11-15
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