Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity

OBJECTIVE: Type 2 diabetes is associated with insulin resistance and skeletal muscle mitochondrial dysfunction. We have found that subjects with early-onset type 2 diabetes show incapacity to increase Vo(2max) in response to chronic exercise. This suggests a defect in muscle mitochondrial response t...

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Detalles Bibliográficos
Autores principales: Hernández-Alvarez, María Isabel, Thabit, Hood, Burns, Nicole, Shah, Syed, Brema, Imad, Hatunic, Mensud, Finucane, Francis, Liesa, Marc, Chiellini, Chiara, Naon, Deborah, Zorzano, Antonio, Nolan, John J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827524/
https://www.ncbi.nlm.nih.gov/pubmed/20032281
http://dx.doi.org/10.2337/dc09-1305

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