Cargando…

α(1A)-Adrenergic Receptor-Directed Autoimmunity Induces Left Ventricular Damage and Diastolic Dysfunction in Rats

BACKGROUND: Agonistic autoantibodies to the α(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is uncertain. METHODS/PRINCIPAL FINDINGS: We immunized Lewis rats with the second extracellular-loop peptides of the human α(1A)-adrenergic rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wenzel, Katrin, Wallukat, Gerd, Qadri, Fatimunnisa, Hubner, Norbert, Schulz, Herbert, Hummel, Oliver, Herse, Florian, Heuser, Arnd, Fischer, Robert, Heidecke, Harald, Luft, Friedrich C., Muller, Dominik N., Dietz, Rainer, Dechend, Ralf
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827566/ https://www.ncbi.nlm.nih.gov/pubmed/20195525 http://dx.doi.org/10.1371/journal.pone.0009409

Ejemplares similares

Potential Relevance of α(1)-Adrenergic Receptor Autoantibodies in Refractory Hypertension
por: Wenzel, Katrin, et al.
Publicado: (2008)

Glaucoma and Alzheimer: Neurodegenerative disorders show an adrenergic dysbalance
por: Hohberger, Bettina, et al.
Publicado: (2022)

Relaxin Does Not Improve Angiotensin II-Induced Target-Organ Damage
por: Haase, Nadine, et al.
Publicado: (2014)

Effects of empagliflozin and target-organ damage in a novel rodent model of heart failure induced by combined hypertension and diabetes
por: Kräker, Kristin, et al.
Publicado: (2020)

Antigen-free control wells in an ELISA set-up for the determination of autoantibodies against G protein-coupled receptors—a requisite for correct data evaluation
por: Haberland, Annekathrin, et al.
Publicado: (2018)

β(1)-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes
por: Park, Misun, et al.
Publicado: (2017)

Difference between beta1-adrenoceptor autoantibodies of human and animal origin—Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology
por: Wenzel, Katrin, et al.
Publicado: (2018)

Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms
por: Wallukat, Gerd, et al.
Publicado: (2021)

Inhibitory and Agonistic Autoantibodies Directed Against the β(2)-Adrenergic Receptor in Pseudoexfoliation Syndrome and Glaucoma
por: Hohberger, Bettina, et al.
Publicado: (2021)

Autoantibodies against M(5)-muscarinic and beta(1)-adrenergic receptors in periodontitis patients
por: Scherbaum, Isabel, et al.
Publicado: (2020)

Autoantibodies directed against α1-adrenergic receptor and endothelin receptor A in patients with prostate cancer
por: Wallukat, Gerd, et al.
Publicado: (2020)

Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy
por: Wenzel, Katrin, et al.
Publicado: (2017)

Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
por: Theuer, Juergen, et al.
Publicado: (2002)

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma
por: Hohberger, Bettina, et al.
Publicado: (2019)

Overexpression of endothelial β(3)‐adrenergic receptor induces diastolic dysfunction in rats
por: Dhot, Justine, et al.
Publicado: (2020)

Agonistic β2-Adrenergic Receptor Autoantibodies Characterize the Aqueous Humor of Patients With Primary and Secondary Open-Angle Glaucoma
por: Hohberger, Bettina, et al.
Publicado: (2021)

Doberman pinschers present autoimmunity associated with functional autoantibodies: A model to study the autoimmune background of human dilated cardiomyopathy
por: Wess, Gerhard, et al.
Publicado: (2019)

The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman Pinschers of efficacy and outcomes
por: Werner, Sabine, et al.
Publicado: (2020)

Anti-inflammatory role of Gpnmb in adipose tissue of mice
por: Nickl, Bernadette, et al.
Publicado: (2021)

Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer
por: Kreienbring, Katrin, et al.
Publicado: (2016)

C-Reactive Protein (CRP) Blocks the Desensitization of Agonistic Stimulated G Protein Coupled Receptors (GPCRs) in Neonatal Rat Cardiomyocytes
por: Wallukat, Gerd, et al.
Publicado: (2022)

Agonistic autoantibodies against ß2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients
por: Hohberger, Bettina, et al.
Publicado: (2021)

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis
por: Karantzali, Efthimia, et al.
Publicado: (2008)

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS
por: Hartwig, Jelka, et al.
Publicado: (2020)

Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma
por: Jünemann, Anselm, et al.
Publicado: (2018)

Functional autoantibodies in patients with different forms of dementia
por: Wallukat, Gerd, et al.
Publicado: (2018)

Correction: Functional autoantibodies in patients with different forms of dementia
por: Wallukat, Gerd, et al.
Publicado: (2018)

Beta-1-Adrenergic Receptor Antibodies in Acute Coronary Syndrome: Is Less Sometimes More?
por: Ernst, Diana, et al.
Publicado: (2018)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker
por: Zadora, Julianna, et al.
Publicado: (2017)

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts
por: Bynke, Annie, et al.
Publicado: (2020)

Compensatory Upregulation of Anti-Beta-Adrenergic Receptor Antibody Levels Might Prevent Heart Failure Presentation in Pediatric Myocarditis
por: Seidel, Franziska, et al.
Publicado: (2022)

Essential role of diastolic oscillatory potentials in adrenergic control of guinea pig sino-atrial node discharge
por: Vassalle, Mario, et al.
Publicado: (2009)

Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME
por: Scheibenbogen, Carmen, et al.
Publicado: (2018)

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
por: Langmia, Immaculate M., et al.
Publicado: (2019)

Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents
por: Mary, Sheon, et al.
Publicado: (2021)

Lowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome
por: Ernst, Diana, et al.
Publicado: (2019)

K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca(2+) release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes
por: Elliott, E. B., et al.
Publicado: (2011)

Effects of Eprosartan on Diastolic Function and Neurohormones in Patients with Hypertension and Diastolic Dysfunction
por: Voors, Adriaan A., et al.
Publicado: (2010)

Negative Adrenergic Feedback Specific to Phospholamban
por: Hasenfuss, Gerd, et al.
Publicado: (2017)

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes
por: Bathe-Peters, Marc, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_og608pdnp02vq59bcik8hglpms