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α(1A)-Adrenergic Receptor-Directed Autoimmunity Induces Left Ventricular Damage and Diastolic Dysfunction in Rats

BACKGROUND: Agonistic autoantibodies to the α(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is uncertain. METHODS/PRINCIPAL FINDINGS: We immunized Lewis rats with the second extracellular-loop peptides of the human α(1A)-adrenergic rec...

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Detalles Bibliográficos
Autores principales:	Wenzel, Katrin, Wallukat, Gerd, Qadri, Fatimunnisa, Hubner, Norbert, Schulz, Herbert, Hummel, Oliver, Herse, Florian, Heuser, Arnd, Fischer, Robert, Heidecke, Harald, Luft, Friedrich C., Muller, Dominik N., Dietz, Rainer, Dechend, Ralf
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827566/ https://www.ncbi.nlm.nih.gov/pubmed/20195525 http://dx.doi.org/10.1371/journal.pone.0009409

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