Variants in FAM13A are associated with chronic obstructive pulmonary disease

Substantial evidence suggests that there is genetic susceptibility to chronic obstructive pulmonary disease (COPD). To identify common genetic risk variants, we performed a genome-wide association study in 2940 cases and 1380 smoking controls with normal lung function. We demonstrate a novel suscept...

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Detalles Bibliográficos
Autores principales: Cho, Michael H., Boutaoui, Nadia, Klanderman, Barbara J., Sylvia, Jody S., Ziniti, John P., Hersh, Craig P., DeMeo, Dawn L., Hunninghake, Gary M., Litonjua, Augusto L., Sparrow, David, Lange, Christoph, Won, Sungho, Murphy, James R., Beaty, Terri, Regan, Elizabeth A., Make, Barry J., Hokanson, John E., Crapo, James D., Kong, Xiangyang Q., Anderson, Wayne H., Tal-Singer, Ruth M., Lomas, David A., Bakke, Per, Gulsvik, Amund, Pillai, Sreekumar G., Silverman, Edwin K.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828499/
https://www.ncbi.nlm.nih.gov/pubmed/20173748
http://dx.doi.org/10.1038/ng.535
Descripción
Sumario:Substantial evidence suggests that there is genetic susceptibility to chronic obstructive pulmonary disease (COPD). To identify common genetic risk variants, we performed a genome-wide association study in 2940 cases and 1380 smoking controls with normal lung function. We demonstrate a novel susceptibility locus at 4q22.1 in FAM13A (rs7671167, OR=0.76, P=8.6×10(−8)) and provide evidence of replication in one case-control and two family-based cohorts (for all studies, combined P=1.2×10(−11)).

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