Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

Antimalarial drugs impose strong pressure on Plasmodium falciparum parasites and leave signatures of selection in the parasite genome 1,2. Search for signals of selection may lead to genes encoding drug or immune targets 3. The lack of high-throughput genotyping methods, inadequate knowledge of para...

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Detalles Bibliográficos
Autores principales: Mu, Jianbing, Myers, Rachel A., Jiang, Hongying, Liu, Shengfa, Ricklefs, Stacy, Waisberg, Michael, Chotivanich, Kesinee, Wilairata, Polrat, Krudsood, Srivicha, White, Nicholas J., Udomsangpetch, Rachanee, Cui, Liwang, Ho, May, Ou, Fengzheng, Li, Haibo, Song, Jiangping, Li, Guoqiao, Wang, Xinhua, Seila, Suon, Sokunthea, Sreng, Socheat, Duong, Sturdevant, Daniel E., Porcella, Stephen F., Fairhurst, Rick M., Wellems, Thomas E., Awadalla, Philip, Su, Xin-zhuan
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828519/
https://www.ncbi.nlm.nih.gov/pubmed/20101240
http://dx.doi.org/10.1038/ng.528

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