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Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

OBJECTIVE: Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice deficient for protein tyrosine phosphatase (PTP)1B display an opposing hepatic phenotype characterized by increased sens...

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Detalles Bibliográficos
Autores principales:	González-Rodríguez, Águeda, Gutierrez, Jose A. Mas, Sanz-González, Silvia, Ros, Manuel, Burks, Deborah J., Valverde, Ángela M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828646/ https://www.ncbi.nlm.nih.gov/pubmed/20028942 http://dx.doi.org/10.2337/db09-0796

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