Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

Small cell lung cancer (SCLC) is an aggressive tumor, associated with ectopic ACTH syndrome. We have shown that SCLC cells are glucocorticoid receptor (GR) deficient, and that restoration of GR expression confers glucocorticoid sensitivity and induces apoptosis in vitro. To determine the effects of...

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Detalles Bibliográficos
Autores principales: Sommer, Paula, Cowen, Rachel L, Berry, Andrew, Cookson, Ann, Telfer, Brian A, Williams, Kaye J, Stratford, Ian J, Kay, Paul, White, Anne, Ray, David W
Formato: Texto
Lenguaje:English
Publicado: Society for Endocrinology 2010
Materias:
Regular papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828806/
https://www.ncbi.nlm.nih.gov/pubmed/20015838
http://dx.doi.org/10.1677/ERC-09-0241

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