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Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore
Rapid chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is dependent on the presence of fixed positive charges in the permeation pathway. Here, we use site-directed mutagenesis and patch clamp recording to show that the functional role played by...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828907/ https://www.ncbi.nlm.nih.gov/pubmed/20142516 http://dx.doi.org/10.1085/jgp.200910327 |