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Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

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Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility to inhibitors of Na(+)/H(+) exchange. Yet, the functional relationship between Na(+)/H(+) exchange and macropinosome formation remains obscure. In A431 cells, stimulation by EGF simultaneously activated m...

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Detalles Bibliográficos
Autores principales:	Koivusalo, Mirkka, Welch, Christopher, Hayashi, Hisayoshi, Scott, Cameron C., Kim, Moshe, Alexander, Todd, Touret, Nicolas, Hahn, Klaus M., Grinstein, Sergio
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828922/ https://www.ncbi.nlm.nih.gov/pubmed/20156964 http://dx.doi.org/10.1083/jcb.200908086

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