Cargando…

Notch regulates the angiogenic response via induction of VEGFR-1

Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Funahashi, Yasuhiro, Shawber, Carrie J, Vorontchikhina, Marina, Sharma, Anshula, Outtz, Hasina H, Kitajewski, Jan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828996/ https://www.ncbi.nlm.nih.gov/pubmed/20298529 http://dx.doi.org/10.1186/2040-2384-2-3

Ejemplares similares

Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity
por: Funahashi, Yasuhiro, et al.
Publicado: (2011)

Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus
por: Shawber, Carrie J., et al.
Publicado: (2015)

VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment
por: Douglas, Nataki C, et al.
Publicado: (2014)

Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis
por: Hernandez, Sonia L, et al.
Publicado: (2013)

Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation
por: Shawber, Carrie J., et al.
Publicado: (2019)

Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization
por: Xu, Haixia, et al.
Publicado: (2012)

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner
por: Pajvani, Utpal B., et al.
Publicado: (2011)

Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
por: Valenti, Luca, et al.
Publicado: (2013)

Lymphatics in health and disease: a new thematic series in vascular cell
por: Kitajewski, Jan, et al.
Publicado: (2013)

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
por: Jovanovic, Vuk P, et al.
Publicado: (2013)

Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice
por: Saeki, Kiyoshi, et al.
Publicado: (2022)

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
por: Sargis, Timothy, et al.
Publicado: (2022)

Unique functions for Notch4 in murine embryonic lymphangiogenesis
por: Muley, Ajit, et al.
Publicado: (2021)

Endothelial Ca(2+) oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo
por: Yokota, Yasuhiro, et al.
Publicado: (2015)

The lymphatic vasculature in lung function and respiratory disease
por: Trivedi, Anjali, et al.
Publicado: (2023)

Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation
por: Munabi, Naikhoba C.O., et al.
Publicado: (2016)

Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy
por: Marchetto, Nicole M., et al.
Publicado: (2020)

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
por: Ragunathrao, Vijay Avin Balaji, et al.
Publicado: (2019)

It's hard to keep all things angiogenic in one JAR!
por: Kitajewski, Jan, et al.
Publicado: (2011)

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
por: Li, Grace X., et al.
Publicado: (2021)

Abstract 11: CD133+ Endothelial Cells Isolated From Venous Malformation Recapitulates Clinical Phenotype in a Mouse Model
por: Grzesik, Peter, et al.
Publicado: (2017)

SALM4 regulates angiogenic functions in endothelial cells through VEGFR2 phosphorylation at Tyr1175
por: Kim, Dong Young, et al.
Publicado: (2019)

Notch1 activates angiogenic regulator Netrin4 in endothelial cells
por: Liu, Qiang, et al.
Publicado: (2019)

Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration
por: Samarajeewa, Anshula, et al.
Publicado: (2019)

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations
por: Kofler, Natalie M., et al.
Publicado: (2015)

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis
por: Thurston, G, et al.
Publicado: (2008)

VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment
por: Patten, Steven G, et al.
Publicado: (2010)

Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature
por: Kim, Bongjune, et al.
Publicado: (2013)

Old Player-New Tricks: Non Angiogenic Effects of the VEGF/VEGFR Pathway in Cancer
por: Ntellas, Panagiotis, et al.
Publicado: (2020)

Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations
por: Davis, Reema B., et al.
Publicado: (2018)

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
por: Hultgren, Nan W., et al.
Publicado: (2020)

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration
por: Swaminathan, Bhairavi, et al.
Publicado: (2022)

Delta-like 4/Notch signaling promotes Apc(Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms
por: Badenes, Marina, et al.
Publicado: (2017)

Angiogenic ability of human endothelial cells was decreased following senescence induction with hydrogen peroxide: possible role of vegfr-2/akt-1 signaling pathway
por: Berenjabad, Nesa Janamo, et al.
Publicado: (2022)

ZLM-7 exhibits anti-angiogenic effects via impaired endothelial cell function and blockade of VEGF/VEGFR-2 signaling
por: Su, Min, et al.
Publicado: (2016)

Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway
por: Ai, Nana, et al.
Publicado: (2018)

Author Correction: Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations
por: Davis, Reema B., et al.
Publicado: (2020)

Erratum to: Delta-like 4/Notch signaling promotes Apc(Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms
por: Badenes, Marina, et al.
Publicado: (2017)

VEGFR2 promotes tumorigenesis and metastasis in a pro-angiogenic-independent way in gastric cancer
por: Lian, Lian, et al.
Publicado: (2019)

Unraveling the Angiogenic Puzzle: Pre-Treatment sVEGFR1 and sVEGFR2 Levels as Promising Prognostic Indicators in Early-Stage Breast Cancer Patients
por: Zarychta, Elżbieta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_g4ssbb90iv3ocolvh819t10l1k