Cargando…

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the cell's leading edge(s), and maturation of nasce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cirit, Murat, Krajcovic, Matej, Choi, Colin K., Welf, Erik S., Horwitz, Alan F., Haugh, Jason M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829041/ https://www.ncbi.nlm.nih.gov/pubmed/20195494 http://dx.doi.org/10.1371/journal.pcbi.1000688

Ejemplares similares

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility
por: Welf, Erik S., et al.
Publicado: (2013)

The Integrin-Ligand Interaction Regulates Adhesion and Migration through a Molecular Clutch
por: Chen, Lingfeng, et al.
Publicado: (2012)

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells
por: Laukaitis, Christina M., et al.
Publicado: (2001)

Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells
por: Vicente-Manzanares, Miguel, et al.
Publicado: (2007)

Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells
por: Vicente-Manzanares, Miguel, et al.
Publicado: (2007)

The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
por: Teckchandani, Anjali, et al.
Publicado: (2016)

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
por: Welf, Erik S., et al.
Publicado: (2012)

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk
por: Wang, Chun-Chao, et al.
Publicado: (2009)

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk
por: Wang, Chun-Chao, et al.
Publicado: (2011)

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132
por: Cirit, Murat, et al.
Publicado: (2012)

Keratocytes Generate High Integrin Tension at the Trailing Edge to Mediate Rear De-adhesion during Rapid Cell Migration
por: Zhao, Yuanchang, et al.
Publicado: (2018)

The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration
por: Broussard, Joshua A., et al.
Publicado: (2012)

Mechanisms of leading edge protrusion in interstitial migration
por: Wilson, Kerry, et al.
Publicado: (2013)

Integrin-mediated Signaling via Paxillin-GIT1-PIX Promotes Localized Rac Activation at the Leading Edge and Cell Migration
por: Li, Youjun, et al.
Publicado: (2020)

Regulation of Dynamic Cell Adhesion by Integrin-Integrin Crosstalk
por: Gahmberg, Carl G., et al.
Publicado: (2022)

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms
por: Schmidt, Samuel, et al.
Publicado: (2009)

Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo
por: Moreira, Carolina G. A., et al.
Publicado: (2013)

Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration
por: Guevara-Garcia, Amaris, et al.
Publicado: (2022)

Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity
por: Huttenlocher, Anna, et al.
Publicado: (1998)

Membrane tension controls adhesion positioning at the leading edge of cells
por: Pontes, Bruno, et al.
Publicado: (2017)

Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal
por: Sastry, Sarita K., et al.
Publicado: (1999)

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells
por: Ezratty, Ellen J., et al.
Publicado: (2009)

Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells
por: Welf, Erik S, et al.
Publicado: (2011)

Integrin β-like 1 protein (ITGBL1) promotes cell migration by preferentially inhibiting integrin-ECM binding at the trailing edge
por: Jang, Dong Gil, et al.
Publicado: (2022)

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration
por: Mostafavi-Pour, Zohreh, et al.
Publicado: (2003)

αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
por: Worth, Daniel C., et al.
Publicado: (2010)

An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration
por: Su, Steven, et al.
Publicado: (2020)

Coupling integrin dynamics to cellular adhesion behaviors
por: Galbraith, Catherine G., et al.
Publicado: (2018)

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion
por: Cunniff, Brian, et al.
Publicado: (2016)

DGK-α keeps integrins close to the edge
por: Mitch, Leslie
Publicado: (2012)

Evolution with Stochastic Fitness and Stochastic Migration
por: Rice, Sean H., et al.
Publicado: (2009)

Leading at The Edge
por: PERKINS, DENNIS
Publicado: (2012)

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration
por: Lagarrigue, Frederic, et al.
Publicado: (2015)

Kindlin-1 Regulates Integrin Dynamics and Adhesion Turnover
por: Margadant, Coert, et al.
Publicado: (2013)

Fidgetin regulates cultured astrocyte migration by severing tyrosinated microtubules at the leading edge
por: Hu, Zunlu, et al.
Publicado: (2017)

Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration
por: Saha, Suvrajit, et al.
Publicado: (2023)

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
por: Mechtersheimer, Sabine, et al.
Publicado: (2001)

Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration
por: Flemming, Sven, et al.
Publicado: (2020)

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior
por: Ioannou, Maria S., et al.
Publicado: (2015)

Leading From the Edge
por: Neal, Annmarie
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gtqqbp6dhf0g71ge29clqi19lf