Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoform...

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Detalles Bibliográficos
Autores principales: Zhou, Ming, Zhao, Yuhua, Ding, Yan, Liu, Hao, Liu, Zixing, Fodstad, Oystein, Riker, Adam I, Kamarajugadda, Sushama, Lu, Jianrong, Owen, Laurie B, Ledoux, Susan P, Tan, Ming
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829492/
https://www.ncbi.nlm.nih.gov/pubmed/20144215
http://dx.doi.org/10.1186/1476-4598-9-33

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