Cargando…
Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation
Group I metabotropic glutamate receptors (mGluRs) are coupled via Gα(q/11 )to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of Ca(2+ )from intracellular stores and the activation of pro...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829546/ https://www.ncbi.nlm.nih.gov/pubmed/20180987 http://dx.doi.org/10.1186/1756-6606-3-4 |