Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

BACKGROUND: The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the cell cycle, we sought to determine if loratadine modifies radiosensitivity in...

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Detalles Bibliográficos
Autores principales: Soule, Benjamin P, Simone, Nicole L, DeGraff, William G, Choudhuri, Rajani, Cook, John A, Mitchell, James B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829588/
https://www.ncbi.nlm.nih.gov/pubmed/20128919
http://dx.doi.org/10.1186/1748-717X-5-8

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