Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor

Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infus...

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Detalles Bibliográficos
Autores principales: Mwirigi, Nicola W., Thomas, Charles F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829622/
https://www.ncbi.nlm.nih.gov/pubmed/20204065
http://dx.doi.org/10.1155/2009/941258
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author Mwirigi, Nicola W.
Thomas, Charles F.
author_facet Mwirigi, Nicola W.
Thomas, Charles F.
author_sort Mwirigi, Nicola W.
collection PubMed
description Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation of the small vessels of the skin with resultant ischemia to the distally supplied areas. To our knowledge, this is the first reported case of presumed hypersensitivity vasculitis following Prolastin infusion.
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spelling pubmed-28296222010-03-04 Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor Mwirigi, Nicola W. Thomas, Charles F. Case Rep Med Case Report Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation of the small vessels of the skin with resultant ischemia to the distally supplied areas. To our knowledge, this is the first reported case of presumed hypersensitivity vasculitis following Prolastin infusion. Hindawi Publishing Corporation 2009 2010-02-24 /pmc/articles/PMC2829622/ /pubmed/20204065 http://dx.doi.org/10.1155/2009/941258 Text en Copyright © 2009 N.W. Mwirigi and C. F. Thomas Jr. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mwirigi, Nicola W.
Thomas, Charles F.
Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title_full Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title_fullStr Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title_full_unstemmed Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title_short Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
title_sort hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829622/
https://www.ncbi.nlm.nih.gov/pubmed/20204065
http://dx.doi.org/10.1155/2009/941258
work_keys_str_mv AT mwiriginicolaw hypersensitivityvasculitiswithleukocytoclasticvasculitisassociatedwithalpha1proteinaseinhibitor
AT thomascharlesf hypersensitivityvasculitiswithleukocytoclasticvasculitisassociatedwithalpha1proteinaseinhibitor

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