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The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences

BACKGROUND: Exposure to prenatal stress is associated with later adverse health and adjustment outcomes. This is generally presumed to arise through early environmentally mediated programming effects on the foetus. However, associations could arise through factors that influence mothers' charac...

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Autores principales: Rice, F., Harold, G. T., Boivin, J., van den Bree, M., Hay, D. F., Thapar, A.
Formato: Texto
Lenguaje:English
Publicado: Cambridge University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830085/
https://www.ncbi.nlm.nih.gov/pubmed/19476689
http://dx.doi.org/10.1017/S0033291709005911
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author Rice, F.
Harold, G. T.
Boivin, J.
van den Bree, M.
Hay, D. F.
Thapar, A.
author_facet Rice, F.
Harold, G. T.
Boivin, J.
van den Bree, M.
Hay, D. F.
Thapar, A.
author_sort Rice, F.
collection PubMed
description BACKGROUND: Exposure to prenatal stress is associated with later adverse health and adjustment outcomes. This is generally presumed to arise through early environmentally mediated programming effects on the foetus. However, associations could arise through factors that influence mothers' characteristics and behaviour during pregnancy which are inherited by offspring. METHOD: A ‘prenatal cross-fostering’ design where pregnant mothers are related or unrelated to their child as a result of in vitro fertilization (IVF) was used to disentangle maternally inherited and environmental influences. If links between prenatal stress and offspring outcome are environmental, association should be observed in unrelated as well as related mother–child pairs. Offspring birth weight and gestational age as well as mental health were the outcomes assessed. RESULTS: Associations between prenatal stress and offspring birth weight, gestational age and antisocial behaviour were seen in both related and unrelated mother–offspring pairs, consistent with there being environmental links. The association between prenatal stress and offspring anxiety in related and unrelated groups appeared to be due to current maternal anxiety/depression rather than prenatal stress. In contrast, the link between prenatal stress and offspring attention deficit hyperactivity disorder was only present in related mother–offspring pairs and therefore was attributable to inherited factors. CONCLUSIONS: Genetically informative designs can be helpful in testing whether inherited factors contribute to the association between environmental risk factors and health outcomes. These results suggest that associations between prenatal stress and offspring outcomes could arise from inherited factors and post-natal environmental factors in addition to causal prenatal risk effects.
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spelling pubmed-28300852010-03-02 The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences Rice, F. Harold, G. T. Boivin, J. van den Bree, M. Hay, D. F. Thapar, A. Psychol Med Original Articles BACKGROUND: Exposure to prenatal stress is associated with later adverse health and adjustment outcomes. This is generally presumed to arise through early environmentally mediated programming effects on the foetus. However, associations could arise through factors that influence mothers' characteristics and behaviour during pregnancy which are inherited by offspring. METHOD: A ‘prenatal cross-fostering’ design where pregnant mothers are related or unrelated to their child as a result of in vitro fertilization (IVF) was used to disentangle maternally inherited and environmental influences. If links between prenatal stress and offspring outcome are environmental, association should be observed in unrelated as well as related mother–child pairs. Offspring birth weight and gestational age as well as mental health were the outcomes assessed. RESULTS: Associations between prenatal stress and offspring birth weight, gestational age and antisocial behaviour were seen in both related and unrelated mother–offspring pairs, consistent with there being environmental links. The association between prenatal stress and offspring anxiety in related and unrelated groups appeared to be due to current maternal anxiety/depression rather than prenatal stress. In contrast, the link between prenatal stress and offspring attention deficit hyperactivity disorder was only present in related mother–offspring pairs and therefore was attributable to inherited factors. CONCLUSIONS: Genetically informative designs can be helpful in testing whether inherited factors contribute to the association between environmental risk factors and health outcomes. These results suggest that associations between prenatal stress and offspring outcomes could arise from inherited factors and post-natal environmental factors in addition to causal prenatal risk effects. Cambridge University Press 2010-02 2009-05-29 /pmc/articles/PMC2830085/ /pubmed/19476689 http://dx.doi.org/10.1017/S0033291709005911 Text en Copyright © Cambridge University Press 2009 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. The written permission of Cambridge University Press must be obtained for commercial re-use. http://creativecommons.org/licenses/by-nc-sa/2.5/ The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. (http://creativecommons.org/licenses/by-nc-sa/2.5/>) The written permission of Cambridge University Press must be obtained for commercial re-use.
spellingShingle Original Articles
Rice, F.
Harold, G. T.
Boivin, J.
van den Bree, M.
Hay, D. F.
Thapar, A.
The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title_full The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title_fullStr The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title_full_unstemmed The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title_short The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
title_sort links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830085/
https://www.ncbi.nlm.nih.gov/pubmed/19476689
http://dx.doi.org/10.1017/S0033291709005911
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