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Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice
BACKGROUND: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that knockout mice for Eps8, a regulator of actin...
Autores principales: | Tocchetti, Arianna, Ekalle Soppo, Charlotte Blanche, Zani, Fabio, Bianchi, Fabrizio, Gagliani, Maria Cristina, Pozzi, Benedetta, Rozman, Jan, Elvert, Ralf, Ehrhardt, Nicole, Rathkolb, Birgit, Moerth, Corinna, Horsch, Marion, Fuchs, Helmut, Gailus-Durner, Valérie, Beckers, Johannes, Klingenspor, Martin, Wolf, Eckhard, de Angelis, Martin Hrabé, Scanziani, Eugenio, Tacchetti, Carlo, Scita, Giorgio, Di Fiore, Pier Paolo, Offenhäuser, Nina |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830459/ https://www.ncbi.nlm.nih.gov/pubmed/20209148 http://dx.doi.org/10.1371/journal.pone.0009468 |
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