Cargando…

Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans

Tumor suppressor candidate 5 (TUSC5) is a gene expressed abundantly in white adipose tissue (WAT), brown adipose tissue (BAT), and peripheral afferent neurons. Strong adipocyte expression and increased expression following peroxisome proliferator activated receptor γ (PPARγ) agonist treatment of 3T3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knotts, Trina A., Lee, Hyun Woo, Kim, Jae Bum, Oort, Pieter J., McPherson, Ruth, Dent, Robert, Tachibana, Keisuke, Doi, Takefumi, Yu, Songtao, Reddy, Janardan K., Uno, Kenji, Katagiri, Hideki, Pasarica, Magdalena, Smith, Steven R., Sears, Dorothy D., Grino, Michel, Adams, Sean H.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830574/ https://www.ncbi.nlm.nih.gov/pubmed/20204174 http://dx.doi.org/10.1155/2009/867678

Ejemplares similares

The Role of PPARs in Cancer
por: Tachibana, Keisuke, et al.
Publicado: (2008)

Evaluation of the Synuclein-γ (SNCG) Gene as a PPARγ Target in Murine Adipocytes, Dorsal Root Ganglia Somatosensory Neurons, and Human Adipose Tissue
por: Dunn, Tamara N., et al.
Publicado: (2015)

The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs
por: Rutnam, Zina Jeyapalan, et al.
Publicado: (2014)

PPARα: energy combustion, hypolipidemia, inflammation and cancer
por: Pyper, Sean R., et al.
Publicado: (2010)

Over-Expression of Two Different Isoforms of Cattle TUSC5 Showed Opposite Effects on Adipogenesis
por: Xia, Han, et al.
Publicado: (2022)

γ-Synuclein Is an Adipocyte-Neuron Gene Coordinately Expressed with Leptin and Increased in Human Obesity
por: Oort, Pieter J., et al.
Publicado: (2008)

TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling
por: Beaton, Nigel, et al.
Publicado: (2015)

TUSC2P suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and correlates with disease prognosis
por: Liu, Fengqiong, et al.
Publicado: (2018)

The effects of aberrant expression of LncRNA DGCR5/miR‐873‐5p/TUSC3 in lung cancer cell progression
por: Luo, Judong, et al.
Publicado: (2018)

Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
por: Yoshida, Takuya, et al.
Publicado: (2020)

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes
por: Fazakerley, Daniel J., et al.
Publicado: (2015)

Decreased TUSC3 Promotes Pancreatic Cancer Proliferation, Invasion and Metastasis
por: Fan, Xiaoqiang, et al.
Publicado: (2016)

Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms
por: Tachibana, Keisuke, et al.
Publicado: (2005)

IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes
por: Luo, Min, et al.
Publicado: (2017)

Correction: Decreased TUSC3 Promotes Pancreatic Cancer Proliferation, Invasion and Metastasis
Publicado: (2016)

TUSC3: a novel tumour suppressor gene and its functional implications
por: Yu, Xinshuang, et al.
Publicado: (2017)

Two Sisters From Qatar With TUSC3 Genetic Mutation: Psychiatric Considerations
por: Albobali, Yahia, et al.
Publicado: (2021)

Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy
por: Arrigo, Austin, et al.
Publicado: (2023)

LncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis
por: Chen, Si, et al.
Publicado: (2019)

LncRNA NR_136400 Suppresses Cell Proliferation and Invasion by Acting as a ceRNA of TUSC5 That Is Modulated by miR-8081 in Osteosarcoma
por: Liu, Liyun, et al.
Publicado: (2020)

miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway
por: Chen, Xiaowen, et al.
Publicado: (2018)

Coactivators in PPAR-Regulated Gene Expression
por: Viswakarma, Navin, et al.
Publicado: (2010)

Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
por: Ivanova, Alla V, et al.
Publicado: (2009)

TUSC3 as a potential biomarker for prognosis in clear cell renal cell carcinoma
por: Yan, Youji, et al.
Publicado: (2019)

TUSC3 Methylation in Peripheral Blood Cells as a Biomarker for Diagnosis of Colorectal Cancer
por: Siri, Goli, et al.
Publicado: (2023)

Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis
por: Zhao, Luqing, et al.
Publicado: (2020)

lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration
por: Wang, Runhui, et al.
Publicado: (2023)

CircRNA hsa_circRNA_0000069 promotes the proliferation, migration and invasion of cervical cancer through miR-873-5p/TUSC3 axis
por: Zhang, Shuaisai, et al.
Publicado: (2020)

PPARs and Liver Disease
por: Kondo, Yasuteru, et al.
Publicado: (2013)

Microtubule nucleating γTuSC assembles structures with 13-fold microtubule-like symmetry
por: Kollman, Justin M., et al.
Publicado: (2010)

TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
por: Horak, Peter, et al.
Publicado: (2014)

The microtubule polymerase Stu2 promotes oligomerization of the γ-TuSC for cytoplasmic microtubule nucleation
por: Gunzelmann, Judith, et al.
Publicado: (2018)

Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211
por: Cong, Menglin, et al.
Publicado: (2019)

LncRNA TUSC8 suppresses the proliferation and migration of esophageal cancer cells by downregulation of VEGFA
por: Hu, Rui, et al.
Publicado: (2021)

Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis
por: Deng, Ruxia, et al.
Publicado: (2022)

Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status
por: Wu, Qiong, et al.
Publicado: (2023)

Metabolic effects of CCL5 deficiency in lean and obese mice
por: Zhou, Hui, et al.
Publicado: (2023)

SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis
por: Liu, Kuancan, et al.
Publicado: (2017)

ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3
por: Ren, Ruizhen, et al.
Publicado: (2021)

Cell-cycle dependent phosphorylation of yeast pericentrin regulates γ-TuSC-mediated microtubule nucleation
por: Lin, Tien-chen, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ad9gr69b5rkp3s57h9tgpvpef3