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The environment within: how gut microbiota may influence metabolism and body composition
Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of energy expenditure through decreased physical act...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830587/ https://www.ncbi.nlm.nih.gov/pubmed/20101384 http://dx.doi.org/10.1007/s00125-010-1662-7 |
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author | Vrieze, A. Holleman, F. Zoetendal, E. G. de Vos, W. M. Hoekstra, J. B. L. Nieuwdorp, M. |
author_facet | Vrieze, A. Holleman, F. Zoetendal, E. G. de Vos, W. M. Hoekstra, J. B. L. Nieuwdorp, M. |
author_sort | Vrieze, A. |
collection | PubMed |
description | Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of energy expenditure through decreased physical activity. In addition, recent studies have focused on intestinal microbiota as environmental factors that increase energy yield from diet, regulate peripheral metabolism and thereby increase body weight. Obesity is associated with substantial changes in composition and metabolic function of gut microbiota, but the pathophysiological processes driving this bidirectional relationship have not been fully elucidated. This review discusses the relationships between the following: composition of gut microbiota, energy extracted from diet, synthesis of gut hormones involved in energy homeostasis, production of butyrate and the regulation of fat storage. |
format | Text |
id | pubmed-2830587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-28305872010-03-15 The environment within: how gut microbiota may influence metabolism and body composition Vrieze, A. Holleman, F. Zoetendal, E. G. de Vos, W. M. Hoekstra, J. B. L. Nieuwdorp, M. Diabetologia Review Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of energy expenditure through decreased physical activity. In addition, recent studies have focused on intestinal microbiota as environmental factors that increase energy yield from diet, regulate peripheral metabolism and thereby increase body weight. Obesity is associated with substantial changes in composition and metabolic function of gut microbiota, but the pathophysiological processes driving this bidirectional relationship have not been fully elucidated. This review discusses the relationships between the following: composition of gut microbiota, energy extracted from diet, synthesis of gut hormones involved in energy homeostasis, production of butyrate and the regulation of fat storage. Springer-Verlag 2010-01-26 2010 /pmc/articles/PMC2830587/ /pubmed/20101384 http://dx.doi.org/10.1007/s00125-010-1662-7 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Vrieze, A. Holleman, F. Zoetendal, E. G. de Vos, W. M. Hoekstra, J. B. L. Nieuwdorp, M. The environment within: how gut microbiota may influence metabolism and body composition |
title | The environment within: how gut microbiota may influence metabolism and body composition |
title_full | The environment within: how gut microbiota may influence metabolism and body composition |
title_fullStr | The environment within: how gut microbiota may influence metabolism and body composition |
title_full_unstemmed | The environment within: how gut microbiota may influence metabolism and body composition |
title_short | The environment within: how gut microbiota may influence metabolism and body composition |
title_sort | environment within: how gut microbiota may influence metabolism and body composition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830587/ https://www.ncbi.nlm.nih.gov/pubmed/20101384 http://dx.doi.org/10.1007/s00125-010-1662-7 |
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