Interleukin 18 in the CNS

Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence home...

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Detalles Bibliográficos
Autores principales: Alboni, Silvia, Cervia, Davide, Sugama, Shuei, Conti, Bruno
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830964/
https://www.ncbi.nlm.nih.gov/pubmed/20113500
http://dx.doi.org/10.1186/1742-2094-7-9
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author Alboni, Silvia
Cervia, Davide
Sugama, Shuei
Conti, Bruno
author_facet Alboni, Silvia
Cervia, Davide
Sugama, Shuei
Conti, Bruno
author_sort Alboni, Silvia
collection PubMed
description Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.
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spelling pubmed-28309642010-03-03 Interleukin 18 in the CNS Alboni, Silvia Cervia, Davide Sugama, Shuei Conti, Bruno J Neuroinflammation Review Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease. BioMed Central 2010-01-29 /pmc/articles/PMC2830964/ /pubmed/20113500 http://dx.doi.org/10.1186/1742-2094-7-9 Text en Copyright ©2010 Alboni et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Alboni, Silvia
Cervia, Davide
Sugama, Shuei
Conti, Bruno
Interleukin 18 in the CNS
title Interleukin 18 in the CNS
title_full Interleukin 18 in the CNS
title_fullStr Interleukin 18 in the CNS
title_full_unstemmed Interleukin 18 in the CNS
title_short Interleukin 18 in the CNS
title_sort interleukin 18 in the cns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830964/
https://www.ncbi.nlm.nih.gov/pubmed/20113500
http://dx.doi.org/10.1186/1742-2094-7-9
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AT sugamashuei interleukin18inthecns
AT contibruno interleukin18inthecns

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