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The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site

BACKGROUND: The p51 subunit of the HIV-1 reverse transcriptase (RT) p66/p51 heterodimer arises from proteolytic cleavage of the RT p66 subunit C-terminal ribonuclease H (RNH) domain during virus maturation. Our previous work showed that mutations in the RT p51↓RNH cleavage site resulted in virus wit...

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Detalles Bibliográficos
Autores principales:	Abram, Michael E, Sarafianos, Stefan G, Parniak, Michael A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831009/ https://www.ncbi.nlm.nih.gov/pubmed/20122159 http://dx.doi.org/10.1186/1742-4690-7-6

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