Cargando…
Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts
BACKGROUND: This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress. METHODS: The in vitro antioxidant potential of the extract was in terms of hydroxyl radical scavenging...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831010/ https://www.ncbi.nlm.nih.gov/pubmed/20180993 http://dx.doi.org/10.1186/1749-8546-5-3 |
_version_ | 1782178201682837504 |
---|---|
author | Kurian, Gino A Suryanarayanan, Srilalitha Raman, Archana Padikkala, Jose |
author_facet | Kurian, Gino A Suryanarayanan, Srilalitha Raman, Archana Padikkala, Jose |
author_sort | Kurian, Gino A |
collection | PubMed |
description | BACKGROUND: This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress. METHODS: The in vitro antioxidant potential of the extract was in terms of hydroxyl radical scavenging activity, lipid peroxide scavenging activity, nitric oxide scavenging activity and diphenylpicrylhydrazyl radical scavenging activity. The in vivo antioxidant potential of the extract was assessed in an isolated rat heart model. RESULTS: Free radicals were scavenged by the extract in a concentration-dependent manner within the range of the given concentrations in all models. Administration of the ethyl acetate extract of Desmodium gangeticum root (100 mg per kg body weight) before global ischemia caused a significant improvement of cardiac function and a decrease in the release of lactate dehydrogenase in coronary effluent, as well as the level of malondialdehyde in myocardial tissues. CONCLUSION: The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia-reperfusion-induced damage in rats. The effects of the extract may be related to the inhibition of lipid peroxidation. |
format | Text |
id | pubmed-2831010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28310102010-03-03 Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts Kurian, Gino A Suryanarayanan, Srilalitha Raman, Archana Padikkala, Jose Chin Med Research BACKGROUND: This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress. METHODS: The in vitro antioxidant potential of the extract was in terms of hydroxyl radical scavenging activity, lipid peroxide scavenging activity, nitric oxide scavenging activity and diphenylpicrylhydrazyl radical scavenging activity. The in vivo antioxidant potential of the extract was assessed in an isolated rat heart model. RESULTS: Free radicals were scavenged by the extract in a concentration-dependent manner within the range of the given concentrations in all models. Administration of the ethyl acetate extract of Desmodium gangeticum root (100 mg per kg body weight) before global ischemia caused a significant improvement of cardiac function and a decrease in the release of lactate dehydrogenase in coronary effluent, as well as the level of malondialdehyde in myocardial tissues. CONCLUSION: The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia-reperfusion-induced damage in rats. The effects of the extract may be related to the inhibition of lipid peroxidation. BioMed Central 2010-01-22 /pmc/articles/PMC2831010/ /pubmed/20180993 http://dx.doi.org/10.1186/1749-8546-5-3 Text en Copyright ©2010 Kurian et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kurian, Gino A Suryanarayanan, Srilalitha Raman, Archana Padikkala, Jose Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title_full | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title_fullStr | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title_full_unstemmed | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title_short | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
title_sort | antioxidant effects of ethyl acetate extract of desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831010/ https://www.ncbi.nlm.nih.gov/pubmed/20180993 http://dx.doi.org/10.1186/1749-8546-5-3 |
work_keys_str_mv | AT kurianginoa antioxidanteffectsofethylacetateextractofdesmodiumgangeticumrootonmyocardialischemiareperfusioninjuryinrathearts AT suryanarayanansrilalitha antioxidanteffectsofethylacetateextractofdesmodiumgangeticumrootonmyocardialischemiareperfusioninjuryinrathearts AT ramanarchana antioxidanteffectsofethylacetateextractofdesmodiumgangeticumrootonmyocardialischemiareperfusioninjuryinrathearts AT padikkalajose antioxidanteffectsofethylacetateextractofdesmodiumgangeticumrootonmyocardialischemiareperfusioninjuryinrathearts |