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Acquired Haemophilia A in the Elderly: Case Reports
Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among el...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831236/ https://www.ncbi.nlm.nih.gov/pubmed/20204184 http://dx.doi.org/10.1155/2010/927503 |
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author | Tufano, Antonella Coppola, Antonio Guida, Anna Cimino, Ernesto De Gregorio, Angela Maria Cerbone, Anna Maria Di Minno, Giovanni |
author_facet | Tufano, Antonella Coppola, Antonio Guida, Anna Cimino, Ernesto De Gregorio, Angela Maria Cerbone, Anna Maria Di Minno, Giovanni |
author_sort | Tufano, Antonella |
collection | PubMed |
description | Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among elderly patients in whom it is frequently associated with malignancy and drugs. This disease often represents a life-threatening bleeding condition, especially in the elderly, thus requiring a prompt therapeutic intervention, including control of acute bleeding and eradication of the inhibitor by immunosuppressive therapy. The diagnosis of AHA should be considered in any elderly patient who presents with bleeding and prolonged activated Partial Thromboplastin Time. Moreover, the coexistence of a series of underlying diseases associated with AHA should be always searched for. An early recognition and an adequate treatment of this coagulation disorder and of the possible associated diseases play a significant role for a favourable outcome, but concomitant morbidities in the elderly may limit aggressive therapy and may complicate the clinical scenario. We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease. |
format | Text |
id | pubmed-2831236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28312362010-03-04 Acquired Haemophilia A in the Elderly: Case Reports Tufano, Antonella Coppola, Antonio Guida, Anna Cimino, Ernesto De Gregorio, Angela Maria Cerbone, Anna Maria Di Minno, Giovanni Curr Gerontol Geriatr Res Case Report Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among elderly patients in whom it is frequently associated with malignancy and drugs. This disease often represents a life-threatening bleeding condition, especially in the elderly, thus requiring a prompt therapeutic intervention, including control of acute bleeding and eradication of the inhibitor by immunosuppressive therapy. The diagnosis of AHA should be considered in any elderly patient who presents with bleeding and prolonged activated Partial Thromboplastin Time. Moreover, the coexistence of a series of underlying diseases associated with AHA should be always searched for. An early recognition and an adequate treatment of this coagulation disorder and of the possible associated diseases play a significant role for a favourable outcome, but concomitant morbidities in the elderly may limit aggressive therapy and may complicate the clinical scenario. We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease. Hindawi Publishing Corporation 2010 2010-03-03 /pmc/articles/PMC2831236/ /pubmed/20204184 http://dx.doi.org/10.1155/2010/927503 Text en Copyright © 2010 Antonella Tufano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Tufano, Antonella Coppola, Antonio Guida, Anna Cimino, Ernesto De Gregorio, Angela Maria Cerbone, Anna Maria Di Minno, Giovanni Acquired Haemophilia A in the Elderly: Case Reports |
title | Acquired Haemophilia A in the Elderly: Case Reports |
title_full | Acquired Haemophilia A in the Elderly: Case Reports |
title_fullStr | Acquired Haemophilia A in the Elderly: Case Reports |
title_full_unstemmed | Acquired Haemophilia A in the Elderly: Case Reports |
title_short | Acquired Haemophilia A in the Elderly: Case Reports |
title_sort | acquired haemophilia a in the elderly: case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831236/ https://www.ncbi.nlm.nih.gov/pubmed/20204184 http://dx.doi.org/10.1155/2010/927503 |
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