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Acquired Haemophilia A in the Elderly: Case Reports

Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among el...

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Autores principales: Tufano, Antonella, Coppola, Antonio, Guida, Anna, Cimino, Ernesto, De Gregorio, Angela Maria, Cerbone, Anna Maria, Di Minno, Giovanni
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831236/
https://www.ncbi.nlm.nih.gov/pubmed/20204184
http://dx.doi.org/10.1155/2010/927503
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author Tufano, Antonella
Coppola, Antonio
Guida, Anna
Cimino, Ernesto
De Gregorio, Angela Maria
Cerbone, Anna Maria
Di Minno, Giovanni
author_facet Tufano, Antonella
Coppola, Antonio
Guida, Anna
Cimino, Ernesto
De Gregorio, Angela Maria
Cerbone, Anna Maria
Di Minno, Giovanni
author_sort Tufano, Antonella
collection PubMed
description Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among elderly patients in whom it is frequently associated with malignancy and drugs. This disease often represents a life-threatening bleeding condition, especially in the elderly, thus requiring a prompt therapeutic intervention, including control of acute bleeding and eradication of the inhibitor by immunosuppressive therapy. The diagnosis of AHA should be considered in any elderly patient who presents with bleeding and prolonged activated Partial Thromboplastin Time. Moreover, the coexistence of a series of underlying diseases associated with AHA should be always searched for. An early recognition and an adequate treatment of this coagulation disorder and of the possible associated diseases play a significant role for a favourable outcome, but concomitant morbidities in the elderly may limit aggressive therapy and may complicate the clinical scenario. We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease.
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spelling pubmed-28312362010-03-04 Acquired Haemophilia A in the Elderly: Case Reports Tufano, Antonella Coppola, Antonio Guida, Anna Cimino, Ernesto De Gregorio, Angela Maria Cerbone, Anna Maria Di Minno, Giovanni Curr Gerontol Geriatr Res Case Report Acquired hemophilia A (AHA) is a very rare disease, caused by the development of autoantibodies, directed against circulating factor VIII of coagulation. Age distribution is bimodal, with a first peak occurring among young women in the postpartum period, and a second major peak of incidence among elderly patients in whom it is frequently associated with malignancy and drugs. This disease often represents a life-threatening bleeding condition, especially in the elderly, thus requiring a prompt therapeutic intervention, including control of acute bleeding and eradication of the inhibitor by immunosuppressive therapy. The diagnosis of AHA should be considered in any elderly patient who presents with bleeding and prolonged activated Partial Thromboplastin Time. Moreover, the coexistence of a series of underlying diseases associated with AHA should be always searched for. An early recognition and an adequate treatment of this coagulation disorder and of the possible associated diseases play a significant role for a favourable outcome, but concomitant morbidities in the elderly may limit aggressive therapy and may complicate the clinical scenario. We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease. Hindawi Publishing Corporation 2010 2010-03-03 /pmc/articles/PMC2831236/ /pubmed/20204184 http://dx.doi.org/10.1155/2010/927503 Text en Copyright © 2010 Antonella Tufano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tufano, Antonella
Coppola, Antonio
Guida, Anna
Cimino, Ernesto
De Gregorio, Angela Maria
Cerbone, Anna Maria
Di Minno, Giovanni
Acquired Haemophilia A in the Elderly: Case Reports
title Acquired Haemophilia A in the Elderly: Case Reports
title_full Acquired Haemophilia A in the Elderly: Case Reports
title_fullStr Acquired Haemophilia A in the Elderly: Case Reports
title_full_unstemmed Acquired Haemophilia A in the Elderly: Case Reports
title_short Acquired Haemophilia A in the Elderly: Case Reports
title_sort acquired haemophilia a in the elderly: case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831236/
https://www.ncbi.nlm.nih.gov/pubmed/20204184
http://dx.doi.org/10.1155/2010/927503
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