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DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism of CFS expression has not been fully elucidated, one known feature is a severely delayed S-phase. We used an in vitro primer extension assay to examine the progression of...

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Detalles Bibliográficos
Autores principales:	Shah, Sandeep N., Opresko, Patricia L., Meng, Xiao, Lee, Marietta Y. W. T., Eckert, Kristin A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831333/ https://www.ncbi.nlm.nih.gov/pubmed/19969545 http://dx.doi.org/10.1093/nar/gkp1131

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