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Role of breast regression protein-39/YKL-40 in asthma and allergic responses
BRP-39 and its human homolog YKL-40 have been regarded as a prototype of chitinase-like proteins (CLP) in mammals. Exaggerated levels of YKL-40 protein and/or mRNA have been noted in a number of diseases characterized by inflammation, tissue remodeling, and aberrant cell growth. Asthma is an inflamm...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831605/ https://www.ncbi.nlm.nih.gov/pubmed/20224674 http://dx.doi.org/10.4168/aair.2010.2.1.20 |
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author | Lee, Chun Geun Elias, Jack A |
author_facet | Lee, Chun Geun Elias, Jack A |
author_sort | Lee, Chun Geun |
collection | PubMed |
description | BRP-39 and its human homolog YKL-40 have been regarded as a prototype of chitinase-like proteins (CLP) in mammals. Exaggerated levels of YKL-40 protein and/or mRNA have been noted in a number of diseases characterized by inflammation, tissue remodeling, and aberrant cell growth. Asthma is an inflammatory disease characterized by airway hyperresponsiveness and airway remodeling. Recently, the novel regulatory role of BRP-39/YKL-40 in the pathogenesis of asthma has been demonstrated both in human studies and allergic animal models. The levels of YKL-40 are increased in the circulation and lungs from asthmatics where they correlate with disease severity, and CHI3L1 polymorphisms correlate with serum YKL-40 levels, asthma and abnormal lung function. Animal studies using BRP-39 null mutant mice demonstrated that BRP-39 was required for optimal allergen sensitization and Th2 inflammation. These studies suggest the potential use of BRP-39 as a biomarker as well as a therapeutic target for asthma and other allergic diseases. Here, we present an overview of chitin/chitinase biology and summarize recent findings on the role of BRP-39 in the pathogenesis of asthma and allergic responses. |
format | Text |
id | pubmed-2831605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-28316052010-03-11 Role of breast regression protein-39/YKL-40 in asthma and allergic responses Lee, Chun Geun Elias, Jack A Allergy Asthma Immunol Res Review BRP-39 and its human homolog YKL-40 have been regarded as a prototype of chitinase-like proteins (CLP) in mammals. Exaggerated levels of YKL-40 protein and/or mRNA have been noted in a number of diseases characterized by inflammation, tissue remodeling, and aberrant cell growth. Asthma is an inflammatory disease characterized by airway hyperresponsiveness and airway remodeling. Recently, the novel regulatory role of BRP-39/YKL-40 in the pathogenesis of asthma has been demonstrated both in human studies and allergic animal models. The levels of YKL-40 are increased in the circulation and lungs from asthmatics where they correlate with disease severity, and CHI3L1 polymorphisms correlate with serum YKL-40 levels, asthma and abnormal lung function. Animal studies using BRP-39 null mutant mice demonstrated that BRP-39 was required for optimal allergen sensitization and Th2 inflammation. These studies suggest the potential use of BRP-39 as a biomarker as well as a therapeutic target for asthma and other allergic diseases. Here, we present an overview of chitin/chitinase biology and summarize recent findings on the role of BRP-39 in the pathogenesis of asthma and allergic responses. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010-01 2009-12-30 /pmc/articles/PMC2831605/ /pubmed/20224674 http://dx.doi.org/10.4168/aair.2010.2.1.20 Text en Copyright © 2010 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lee, Chun Geun Elias, Jack A Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title | Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title_full | Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title_fullStr | Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title_full_unstemmed | Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title_short | Role of breast regression protein-39/YKL-40 in asthma and allergic responses |
title_sort | role of breast regression protein-39/ykl-40 in asthma and allergic responses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831605/ https://www.ncbi.nlm.nih.gov/pubmed/20224674 http://dx.doi.org/10.4168/aair.2010.2.1.20 |
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