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Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy

Rats trained in a dual-solution cross-maze task, which can be solved by place and response strategies, predominantly used a response strategy after extensive training. This paper examines the involvement of the medial and lateral dorsal striatum (mDS and lDS) in the choice of these strategies after...

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Detalles Bibliográficos
Autores principales: Botreau, Fanny, Gisquet-Verrier, Pascale
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831625/
https://www.ncbi.nlm.nih.gov/pubmed/20204137
http://dx.doi.org/10.3389/neuro.08.007.2010
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author Botreau, Fanny
Gisquet-Verrier, Pascale
author_facet Botreau, Fanny
Gisquet-Verrier, Pascale
author_sort Botreau, Fanny
collection PubMed
description Rats trained in a dual-solution cross-maze task, which can be solved by place and response strategies, predominantly used a response strategy after extensive training. This paper examines the involvement of the medial and lateral dorsal striatum (mDS and lDS) in the choice of these strategies after partial and extensive training. Our results show that rats with lDS and mDS lesions used mainly a response strategy from the early phase of training. We replicated these unexpected data in rats with lDS lesions and confirmed their tendency to use the response strategy in a modified cross-maze task. When trained in a dual-solution water-maze task, however, control and lesioned rats consistently used a place strategy, demonstrating that lDS and mDS lesioned rats can use a place strategy and that the shift towards a response strategy did not systematically result from extensive training. The present data did not show any clear dissociation between the mDS and lDS in dual solution tasks. They further indicate that the dorsal striatum seems to determine the strategies adopted in a particular context but cannot be considered as a neural support for the response memory system. Accordingly, the role of the lateral and medial part of the dorsal striatum in egocentric/response memory should be reconsidered.
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spelling pubmed-28316252010-03-04 Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy Botreau, Fanny Gisquet-Verrier, Pascale Front Behav Neurosci Neuroscience Rats trained in a dual-solution cross-maze task, which can be solved by place and response strategies, predominantly used a response strategy after extensive training. This paper examines the involvement of the medial and lateral dorsal striatum (mDS and lDS) in the choice of these strategies after partial and extensive training. Our results show that rats with lDS and mDS lesions used mainly a response strategy from the early phase of training. We replicated these unexpected data in rats with lDS lesions and confirmed their tendency to use the response strategy in a modified cross-maze task. When trained in a dual-solution water-maze task, however, control and lesioned rats consistently used a place strategy, demonstrating that lDS and mDS lesioned rats can use a place strategy and that the shift towards a response strategy did not systematically result from extensive training. The present data did not show any clear dissociation between the mDS and lDS in dual solution tasks. They further indicate that the dorsal striatum seems to determine the strategies adopted in a particular context but cannot be considered as a neural support for the response memory system. Accordingly, the role of the lateral and medial part of the dorsal striatum in egocentric/response memory should be reconsidered. Frontiers Research Foundation 2010-02-26 /pmc/articles/PMC2831625/ /pubmed/20204137 http://dx.doi.org/10.3389/neuro.08.007.2010 Text en Copyright © 2010 Botreau and Gisquet-Verrier. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Botreau, Fanny
Gisquet-Verrier, Pascale
Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title_full Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title_fullStr Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title_full_unstemmed Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title_short Re-Thinking the Role of the Dorsal Striatum in Egocentric/Response Strategy
title_sort re-thinking the role of the dorsal striatum in egocentric/response strategy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831625/
https://www.ncbi.nlm.nih.gov/pubmed/20204137
http://dx.doi.org/10.3389/neuro.08.007.2010
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