Increased susceptibility of Huh7 cells to HCV replication does not require mutations in RIG-I

BACKGROUND: The cytosolic retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that senses HCV double-stranded RNA and triggers type I interferon pathways. The clone Huh7.5 of human hepatoma Huh7 cells contains a mutation in RIG-I that is believed to be responsible for the improv...

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Detalles Bibliográficos
Autores principales: Feigelstock, Dino A, Mihalik, Kathleen B, Kaplan, Gerardo, Feinstone, Stephen M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831881/
https://www.ncbi.nlm.nih.gov/pubmed/20170495
http://dx.doi.org/10.1186/1743-422X-7-44

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