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Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis
BACKGROUND: Chlamydia trachomatis infections are the most prevalent sexually transmitted bacterial infections in the world. There is scarce data available referring to the distribution of C. trachomatis genotypes in Argentina. The aim of this study was to identify the genotypes of C. trachomatis cir...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831911/ https://www.ncbi.nlm.nih.gov/pubmed/20181127 http://dx.doi.org/10.1186/1756-0500-3-34 |
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author | Gallo Vaulet, Lucía Entrocassi, Carolina Corominas, Ana I Rodríguez Fermepin, Marcelo |
author_facet | Gallo Vaulet, Lucía Entrocassi, Carolina Corominas, Ana I Rodríguez Fermepin, Marcelo |
author_sort | Gallo Vaulet, Lucía |
collection | PubMed |
description | BACKGROUND: Chlamydia trachomatis infections are the most prevalent sexually transmitted bacterial infections in the world. There is scarce data available referring to the distribution of C. trachomatis genotypes in Argentina. The aim of this study was to identify the genotypes of C. trachomatis circulating in the metropolitan area of Buenos Aires (Argentina) associated with ophthalmia neonatorum and genital infections. FINDINGS: From 2001 to 2006, 199 positive samples for C. trachomatis infection from symptomatic adult patients and neonates with ophthalmia neonatorum from two public hospitals were studied. C. trachomatis genotypes were determined by PCR-RFLP of an ompA fragment. Genotype E was the most prevalent regardless of the sample origin (46.3% 57/123 in adults and 72.4% 55/76 in neonates), followed by genotype D (19.5% 24/123) and F (14.6% 18/123) in adults, and G (9.2% 7/76) and D (7.9% 6/76) in neonates. We detected a significantly higher frequency of genotype E (p < 0.001, OR = 3.03 (1.57<OR<5.90)) in ophthalmia neonatorum than in genital specimens. Genotype D was associated with genital localization (p < 0.05, OR = 2.83 (1.03<OR<8.18)). CONCLUSION: We found a particularly increased frequency of C. trachomatis genotype E in neonatal conjunctivitis, which may indicate an epidemiological association between this genotype and the newborn population. The present study also contributed to increase the knowledge on genotype distribution of Chlamydia trachomatis in symptomatic adult patients in Buenos Aires, Argentina, in which genotypes E, D and F were the predominant ones. |
format | Text |
id | pubmed-2831911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28319112010-03-04 Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis Gallo Vaulet, Lucía Entrocassi, Carolina Corominas, Ana I Rodríguez Fermepin, Marcelo BMC Res Notes Short Report BACKGROUND: Chlamydia trachomatis infections are the most prevalent sexually transmitted bacterial infections in the world. There is scarce data available referring to the distribution of C. trachomatis genotypes in Argentina. The aim of this study was to identify the genotypes of C. trachomatis circulating in the metropolitan area of Buenos Aires (Argentina) associated with ophthalmia neonatorum and genital infections. FINDINGS: From 2001 to 2006, 199 positive samples for C. trachomatis infection from symptomatic adult patients and neonates with ophthalmia neonatorum from two public hospitals were studied. C. trachomatis genotypes were determined by PCR-RFLP of an ompA fragment. Genotype E was the most prevalent regardless of the sample origin (46.3% 57/123 in adults and 72.4% 55/76 in neonates), followed by genotype D (19.5% 24/123) and F (14.6% 18/123) in adults, and G (9.2% 7/76) and D (7.9% 6/76) in neonates. We detected a significantly higher frequency of genotype E (p < 0.001, OR = 3.03 (1.57<OR<5.90)) in ophthalmia neonatorum than in genital specimens. Genotype D was associated with genital localization (p < 0.05, OR = 2.83 (1.03<OR<8.18)). CONCLUSION: We found a particularly increased frequency of C. trachomatis genotype E in neonatal conjunctivitis, which may indicate an epidemiological association between this genotype and the newborn population. The present study also contributed to increase the knowledge on genotype distribution of Chlamydia trachomatis in symptomatic adult patients in Buenos Aires, Argentina, in which genotypes E, D and F were the predominant ones. BioMed Central 2010-02-09 /pmc/articles/PMC2831911/ /pubmed/20181127 http://dx.doi.org/10.1186/1756-0500-3-34 Text en Copyright ©2010 Vaulet et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Gallo Vaulet, Lucía Entrocassi, Carolina Corominas, Ana I Rodríguez Fermepin, Marcelo Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title | Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title_full | Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title_fullStr | Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title_full_unstemmed | Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title_short | Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis |
title_sort | distribution study of chlamydia trachomatis genotypes in symptomatic patients in buenos aires, argentina: association between genotype e and neonatal conjunctivitis |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831911/ https://www.ncbi.nlm.nih.gov/pubmed/20181127 http://dx.doi.org/10.1186/1756-0500-3-34 |
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