Computational Model of Steroidogenesis in Human H295R Cells to Predict Biochemical Response to Endocrine-Active Chemicals: Model Development for Metyrapone

Background: An in vitro steroidogenesis assay using the human adrenocortical carcinoma cell line H295R is being evaluated as a possible screening assay to detect and assess the impact of endocrine-active chemicals (EACs) capable of altering steroid biosynthesis. Data interpretation and their quantit...

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Detalles Bibliográficos
Autores principales: Breen, Michael S., Breen, Miyuki, Terasaki, Natsuko, Yamazaki, Makoto, Conolly, Rory B.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831928/
https://www.ncbi.nlm.nih.gov/pubmed/20123619
http://dx.doi.org/10.1289/ehp.0901107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831928/
https://www.ncbi.nlm.nih.gov/pubmed/20123619
http://dx.doi.org/10.1289/ehp.0901107

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