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Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients
Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helix-distorting DNA lesions, such as UV–induced photodimers, from the genome. Patients suffering from XP exhibit exquisite sun sensitivity, high incidence of skin cancer, and in some cases n...
Autores principales: | Ahmad, Anwaar, Enzlin, Jacqueline H., Bhagwat, Nikhil R., Wijgers, Nils, Raams, Anja, Appledoorn, Esther, Theil, Arjan F., J. Hoeijmakers, Jan H., Vermeulen, Wim, J. Jaspers, Nicolaas G., Schärer, Orlando D., Niedernhofer, Laura J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832669/ https://www.ncbi.nlm.nih.gov/pubmed/20221251 http://dx.doi.org/10.1371/journal.pgen.1000871 |
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