Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with a tiny number of complexes being drugged. Such intricate biological systems cannot b...

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Detalles Bibliográficos
Autores principales: Reynès, Christelle, Host, Hélène, Camproux, Anne-Claude, Laconde, Guillaume, Leroux, Florence, Mazars, Anne, Deprez, Benoit, Fahraeus, Robin, Villoutreix, Bruno O., Sperandio, Olivier
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832677/
https://www.ncbi.nlm.nih.gov/pubmed/20221258
http://dx.doi.org/10.1371/journal.pcbi.1000695

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