Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8(+) T Cells

The prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific CD8(+) T cells is directly proportional to the number of functions they can perform, with IL-2 production capacity considered critical. Having recently defined rapid perforin upregu...

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Detalles Bibliográficos
Autores principales: Makedonas, George, Hutnick, Natalie, Haney, Danielle, Amick, Alexandra C., Gardner, Jay, Cosma, Gabriela, Hersperger, Adam R., Dolfi, Douglas, Wherry, E. John, Ferrari, Guido, Betts, Michael R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832688/
https://www.ncbi.nlm.nih.gov/pubmed/20221423
http://dx.doi.org/10.1371/journal.ppat.1000798

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