Cargando…

The Type 1 Diabetes - HLA Susceptibility Interactome - Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes

BACKGROUND: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brorsson, Caroline, Tue Hansen, Niclas, Bergholdt, Regine, Brunak, Søren, Pociot, Flemming
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832689/ https://www.ncbi.nlm.nih.gov/pubmed/20221424 http://dx.doi.org/10.1371/journal.pone.0009576

Ejemplares similares

Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes
por: Bergholdt, Regine, et al.
Publicado: (2009)

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
por: Bergholdt, Regine, et al.
Publicado: (2012)

No Difference in Vitamin D Levels Between Children Newly Diagnosed With Type 1 Diabetes and Their Healthy Siblings: A 13-Year Nationwide Danish Study
por: Thorsen, Steffen U., et al.
Publicado: (2013)

Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control
por: Brorsson, Caroline A., et al.
Publicado: (2016)

HLA genotyping in the international Type 1 Diabetes Genetics Consortium
por: Mychaleckyj, Josyf C, et al.
Publicado: (2010)

Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans
por: Kwak, Soo Heon, et al.
Publicado: (2015)

Multiple HLA Epitopes Contribute to Type 1 Diabetes Susceptibility
por: Roark, Christina L., et al.
Publicado: (2014)

Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes
por: Saare, Liisa, et al.
Publicado: (2022)

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
por: Bergholdt, Regine, et al.
Publicado: (2007)

Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
por: Kaur, Simranjeet, et al.
Publicado: (2015)

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium
por: Noble, Janelle A., et al.
Publicado: (2010)

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
por: Concannon, Patrick, et al.
Publicado: (2008)

Type 1 diabetes genome-wide association studies: not to be lost in translation
por: Pociot, Flemming
Publicado: (2017)

Receiver Operating Characteristic Analysis of HLA, CTLA4, and Insulin Genotypes for Type 1 Diabetes
por: Valdes, Ana M., et al.
Publicado: (2013)

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus
por: Soetjipto,, et al.
Publicado: (2022)

Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth With Type 1 Diabetes
por: Vehik, Kendra, et al.
Publicado: (2008)

Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes
por: Zhou, Zemin, et al.
Publicado: (2013)

Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes
por: Sticht, Jana, et al.
Publicado: (2021)

Association of the HLA-DQA1 and HLA-DQB1 Alleles in Type 2 Diabetes Mellitus and Diabetic Nephropathy in the Han Ethnicity of China
por: Ma, Ze-Jun, et al.
Publicado: (2013)

Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios
por: Matey-Hernandez, Maria Luisa, et al.
Publicado: (2018)

Do Non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children With High-Risk HLA-DR,DQ Genotypes?
por: Steck, Andrea K., et al.
Publicado: (2009)

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
por: Reinauer, Christina, et al.
Publicado: (2017)

Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies
por: Maziarz, M, et al.
Publicado: (2015)

What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
por: Wyatt, Rebecca C., et al.
Publicado: (2019)

HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, Are More Expressed Than Non-Predisposing Alleles and Are Coordinately Regulated
por: Farina, Federica, et al.
Publicado: (2019)

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms
por: Nguyen, Cao, et al.
Publicado: (2013)

Celiac Disease and Autoimmune Thyroid Disease in Children with Type 1 Diabetes Mellitus: Clinical and HLA−Genotyping Results
por: Ergür, Ayça Törel, et al.
Publicado: (2010)

HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study
por: Fagbemi, Kaossarath A., et al.
Publicado: (2017)

The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations
por: Deja, Grazyna, et al.
Publicado: (2020)

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes
por: Parkkola, Anna, et al.
Publicado: (2017)

HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing
por: Megiorni, Francesca, et al.
Publicado: (2012)

HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes
por: Scotto, Matthieu, et al.
Publicado: (2012)

HLA-C downregulation by HIV-1 adapts to host HLA genotype
por: Bachtel, Nathaniel D., et al.
Publicado: (2018)

Residual β-Cell Function 3–6 Years After Onset of Type 1 Diabetes Reduces Risk of Severe Hypoglycemia in Children and Adolescents
por: Sørensen, Jesper S., et al.
Publicado: (2013)

Association of interleukin-4, interleukin-13 gene polymorphisms, HLA-DQ and DR genotypes with genetic susceptibility of type-1 Diabetes Mellitus in Kuwaiti children
por: Haider, Mohammad Z., et al.
Publicado: (2023)

PDE12 in type 1 diabetes
por: Tekin, Hasim, et al.
Publicado: (2022)

Development of Type 1 Diabetes may occur through a Type 2 Diabetes mechanism
por: Josefsen, Knud, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kf9alghadhc2fkgmhhccou71gh