Modification of Superoxide Dismutase 1 (SOD1) Properties by a GFP Tag – Implications for Research into Amyotrophic Lateral Sclerosis (ALS)

BACKGROUND: Since the discovery that mutations in the enzyme SOD1 are causative in human amyotrophic lateral sclerosis (ALS), many strategies have been employed to elucidate the toxic properties of this ubiquitously expressed mutant protein, including the generation of GFP-SOD1 chimaeric proteins fo...

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Detalles Bibliográficos
Autores principales: Stevens, James C., Chia, Ruth, Hendriks, William T., Bros-Facer, Virginie, van Minnen, Jan, Martin, Joanne E., Jackson, Graham S., Greensmith, Linda, Schiavo, Giampietro, Fisher, Elizabeth M. C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833207/
https://www.ncbi.nlm.nih.gov/pubmed/20221404
http://dx.doi.org/10.1371/journal.pone.0009541

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